Abstract tRNAs are key adaptor molecules that decipher the genetic code during translation
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …

RNA polymerase (Pol) III is responsible for transcription of different noncoding genes in
eukaryotic cells, whose RNA products have well-defined functions in translation and other …

RNA polymerase (Pol) III transcribes small untranslated RNAs such as 5S ribosomal RNA,
transfer RNAs, and U6 small nuclear RNA. Because of the functions of these RNAs, Pol III …

Ribosomes are macromolecular machines that are globally required for the translation of all
proteins in all cells. Ribosome biogenesis, which is essential for cell growth, proliferation …

Abstract RNA polymerase III (Pol III)-related hypomyelinating leukodystrophy (POLR3-HLD),
also known as 4H leukodystrophy, is a severe neurodegenerative disease characterized by …

Molecular chaperones are critical for protein homeostasis and are implicated in several
human pathologies such as neurodegeneration and cancer. While the binding of …

Background RNA polymerase III-related or 4H leukodystrophy (POLR3-HLD) is an
autosomal recessive hypomyelinating leukodystrophy characterized by neurological …

Hypomyelinating leukodystrophy (HLD) is a rare genetic heterogeneous disease that can
affect myelin development in the central nervous system. This study aims to analyze the …

Introduction RNA polymerase III (Pol III) is a critical enzymatic complex tasked with the
transcription of ubiquitous non-coding RNAs including 5S rRNA and all tRNA genes …

Objective To expand the phenotypic spectrum of severity of POLR3-related leukodystrophy
and identify genotype-phenotype correlations through study of patients with extremely …