Mitochondrial mechanisms in Alzheimer's disease: Quest for therapeutics
K Kalani, P Chaturvedi, P Chaturvedi, VK Verma… - Drug Discovery …, 2023 - Elsevier
Highlights•Mitochondria decide the progression of Alzheimer's disease.•AD pathology and
severity are determined by mitochondrial dynamics and energetic mechanisms.•Mitophagy …
severity are determined by mitochondrial dynamics and energetic mechanisms.•Mitophagy …
[HTML][HTML] Ketogenic diets and Ketone suplementation: A strategy for therapeutic intervention
CGJ Saris, S Timmers - Frontiers in Nutrition, 2022 - frontiersin.org
Ketogenic diets and orally administered exogenous ketone supplements are strategies to
increase serum ketone bodies serving as an alternative energy fuel for high energy …
increase serum ketone bodies serving as an alternative energy fuel for high energy …
[HTML][HTML] Localized proteomic differences in the choroid plexus of Alzheimer's disease and epilepsy patients
DF Leitner, E Kanshin, A Faustin, M Thierry… - Frontiers in …, 2023 - frontiersin.org
Introduction Alzheimer's disease (AD) and epilepsy are reciprocally related. Among sporadic
AD patients, clinical seizures occur in 10–22% and subclinical epileptiform abnormalities …
AD patients, clinical seizures occur in 10–22% and subclinical epileptiform abnormalities …
D-beta-hydroxybutyrate protects against microglial activation in lipopolysaccharide-treated mice and BV-2 cells
Y Zhang, K Liu, Y Li, Y Ma, Y Wang, Z Fan, Y Li… - Metabolic Brain …, 2023 - Springer
Microglial activation is a key event in neuroinflammation, which, in turn, is a central process
in neurological disorders. In this study, we investigated the protective effects of D-beta …
in neurological disorders. In this study, we investigated the protective effects of D-beta …
[HTML][HTML] Lipid and glucose metabolism in senescence
B Liu, Q Meng, X Gao, H Sun, Z Xu, Y Wang… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Senescence is an inevitable biological process. Disturbances in glucose and lipid
metabolism are essential features of cellular senescence. Given the important roles of these …
metabolism are essential features of cellular senescence. Given the important roles of these …
Metabolomic, proteomic, and transcriptomic changes in adults with epilepsy on modified Atkins diet
Objective High‐fat and low‐carbohydrate diets can reduce seizure frequency in some
treatment‐resistant epilepsy patients, including the more flexible modified Atkins diet (MAD) …
treatment‐resistant epilepsy patients, including the more flexible modified Atkins diet (MAD) …
[HTML][HTML] Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-κB signaling pathways
J Jiang, H Pan, F Shen, Y Tan… - Neural Regeneration …, 2023 - journals.lww.com
Alzheimer's disease is a progressive neurological disorder characterized by cognitive
decline and chronic inflammation within the brain. The ketogenic diet, a widely recognized …
decline and chronic inflammation within the brain. The ketogenic diet, a widely recognized …
Neuroprotective mechanisms of OXCT1 via the SIRT3-SOD2 pathway after traumatic brain injury
YS Zhuang, X Wang, SQ Gao, SH Miao, T Li, CC Gao… - Brain Research, 2023 - Elsevier
Background Ketones are not only utilized to produce energy but also play a neuroprotective
role in many neurodegenerative diseases. However, whether this process has an impact on …
role in many neurodegenerative diseases. However, whether this process has an impact on …
[HTML][HTML] A bibliometric analysis of the global trends and hotspots for the ketogenic diet based on CiteSpace
R Ye, Y Cheng, Y Ge, G Xu, W Tu - Medicine, 2023 - journals.lww.com
The ketogenic diet (KD) is a potential nutritional therapy that is frequently utilized in various
conditions. More and more studies are being done on KD in recent years. However, as far as …
conditions. More and more studies are being done on KD in recent years. However, as far as …
[HTML][HTML] Potential diets to improve mitochondrial activity in amyotrophic lateral sclerosis
S Yoshikawa, K Taniguchi, H Sawamura, Y Ikeda… - Diseases, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease, the
pathogenesis of which is based on alternations in the mitochondria of motor neurons …
pathogenesis of which is based on alternations in the mitochondria of motor neurons …