Mitochondrial mechanisms in Alzheimer's disease: Quest for therapeutics

K Kalani, P Chaturvedi, P Chaturvedi, VK Verma… - Drug Discovery …, 2023 - Elsevier
Highlights•Mitochondria decide the progression of Alzheimer's disease.•AD pathology and
severity are determined by mitochondrial dynamics and energetic mechanisms.•Mitophagy …

[HTML][HTML] Ketogenic diets and Ketone suplementation: A strategy for therapeutic intervention

CGJ Saris, S Timmers - Frontiers in Nutrition, 2022 - frontiersin.org
Ketogenic diets and orally administered exogenous ketone supplements are strategies to
increase serum ketone bodies serving as an alternative energy fuel for high energy …

[HTML][HTML] Localized proteomic differences in the choroid plexus of Alzheimer's disease and epilepsy patients

DF Leitner, E Kanshin, A Faustin, M Thierry… - Frontiers in …, 2023 - frontiersin.org
Introduction Alzheimer's disease (AD) and epilepsy are reciprocally related. Among sporadic
AD patients, clinical seizures occur in 10–22% and subclinical epileptiform abnormalities …

D-beta-hydroxybutyrate protects against microglial activation in lipopolysaccharide-treated mice and BV-2 cells

Y Zhang, K Liu, Y Li, Y Ma, Y Wang, Z Fan, Y Li… - Metabolic Brain …, 2023 - Springer
Microglial activation is a key event in neuroinflammation, which, in turn, is a central process
in neurological disorders. In this study, we investigated the protective effects of D-beta …

[HTML][HTML] Lipid and glucose metabolism in senescence

B Liu, Q Meng, X Gao, H Sun, Z Xu, Y Wang… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Senescence is an inevitable biological process. Disturbances in glucose and lipid
metabolism are essential features of cellular senescence. Given the important roles of these …

Metabolomic, proteomic, and transcriptomic changes in adults with epilepsy on modified Atkins diet

DF Leitner, Y Siu, A Korman, Z Lin, E Kanshin… - …, 2023 - Wiley Online Library
Objective High‐fat and low‐carbohydrate diets can reduce seizure frequency in some
treatment‐resistant epilepsy patients, including the more flexible modified Atkins diet (MAD) …

[HTML][HTML] Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-κB signaling pathways

J Jiang, H Pan, F Shen, Y Tan… - Neural Regeneration …, 2023 - journals.lww.com
Alzheimer's disease is a progressive neurological disorder characterized by cognitive
decline and chronic inflammation within the brain. The ketogenic diet, a widely recognized …

Neuroprotective mechanisms of OXCT1 via the SIRT3-SOD2 pathway after traumatic brain injury

YS Zhuang, X Wang, SQ Gao, SH Miao, T Li, CC Gao… - Brain Research, 2023 - Elsevier
Background Ketones are not only utilized to produce energy but also play a neuroprotective
role in many neurodegenerative diseases. However, whether this process has an impact on …

[HTML][HTML] A bibliometric analysis of the global trends and hotspots for the ketogenic diet based on CiteSpace

R Ye, Y Cheng, Y Ge, G Xu, W Tu - Medicine, 2023 - journals.lww.com
The ketogenic diet (KD) is a potential nutritional therapy that is frequently utilized in various
conditions. More and more studies are being done on KD in recent years. However, as far as …

[HTML][HTML] Potential diets to improve mitochondrial activity in amyotrophic lateral sclerosis

S Yoshikawa, K Taniguchi, H Sawamura, Y Ikeda… - Diseases, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease, the
pathogenesis of which is based on alternations in the mitochondria of motor neurons …