Extended-spectrum β-lactamase (ESBL)-producing Gram-negative pathogens are a major
cause of resistance to expanded-spectrum β-lactam antibiotics. Since their discovery in the …

Therapy of invasive infections due to multidrug-resistant Enterobacteriaceae (MDR-E) is
challenging, and some of the few active drugs are not available in many countries. For …

Escherichia coli sequence type 131 (ST131) and Klebsiella pneumoniae ST258 emerged in
the 2000s as important human pathogens, have spread extensively throughout the world …

Escherichia coli is one of the most-studied microorganisms worldwide but its characteristics
are continually changing. Extraintestinal E. coli infections, such as urinary tract infections …

Healthcare‐associated infections due to multidrug‐resistant Gram‐negative bacteria (MDR‐
GNB) are a leading cause of morbidity and mortality worldwide. These evidence‐based …

Abstract Multidrug-resistant (MDR) Gram-negative bacteria (GNB) pose a critical threat to
global healthcare, worsening outcomes and increasing mortality among infected patients …

CTX-M β-lactamases are considered a paradigm in the evolution of a resistance
mechanism. Incorporation of different chromosomal bla CTX-M related genes from different …

Plasmid-acquired carbapenemases in Enterobacteriaceae, which were first discovered in
Europe in the 1990s, are now increasingly being identified at an alarming rate. Although …

Background A total of 178 825 Enterobacteriaceae isolates collected in 199 hospitals from
42 countries worldwide over 20 years (1997 to 2016) of the SENTRY Program were …

Antimicrobial resistance (AMR) represents a major threat to human and animal health. Part
of the AMR dimension is the circulation of extended-spectrum β-lactamases producing …