Time for united action on depression: a Lancet–World Psychiatric Association Commission

H Herrman, V Patel, C Kieling, M Berk, C Buchweitz… - The Lancet, 2022 - thelancet.com
Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

Physical activity and depression: Towards understanding the antidepressant mechanisms of physical activity

A Kandola, G Ashdown-Franks, J Hendrikse… - Neuroscience & …, 2019 - Elsevier
Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

Quantifying deviations of brain structure and function in major depressive disorder across neuroimaging modalities

NR Winter, R Leenings, J Ernsting, K Sarink… - JAMA …, 2022 - jamanetwork.com
Importance Identifying neurobiological differences between patients with major depressive
disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for …

Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model

RB Price, R Duman - Molecular psychiatry, 2020 - nature.com
Chronic stress and depressive-like behaviors in basic neuroscience research have been
associated with impairments of neuroplasticity, such as neuronal atrophy and synaptic loss …

Major depressive disorder: advances in neuroscience research and translational applications

Z Li, M Ruan, J Chen, Y Fang - Neuroscience bulletin, 2021 - Springer
Major depressive disorder (MDD), also referred to as depression, is one of the most common
psychiatric disorders with a high economic burden. The etiology of depression is still not …

The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders

G Sanacora, Z Yan, M Popoli - Nature Reviews Neuroscience, 2022 - nature.com
Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …

Connectome gradient dysfunction in major depression and its association with gene expression profiles and treatment outcomes

M Xia, J Liu, A Mechelli, X Sun, Q Ma, X Wang… - Molecular …, 2022 - nature.com
Patients with major depressive disorder (MDD) exhibit concurrent deficits in both sensory
and higher-order cognitive processing. Connectome studies have suggested a principal …

[HTML][HTML] Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan

R Pomponio, G Erus, M Habes, J Doshi, D Srinivasan… - NeuroImage, 2020 - Elsevier
As medical imaging enters its information era and presents rapidly increasing needs for big
data analytics, robust pooling and harmonization of imaging data across diverse cohorts …

Sex differences in depression: Insights from clinical and preclinical studies

RS Eid, AR Gobinath, LAM Galea - Progress in neurobiology, 2019 - Elsevier
Depression represents a global mental health concern, and disproportionally affects women
as they are twice more likely to be diagnosed than men. In this review, we provide a …

Reduced default mode network functional connectivity in patients with recurrent major depressive disorder

CG Yan, X Chen, L Li, FX Castellanos… - Proceedings of the …, 2019 - National Acad Sciences
Major depressive disorder (MDD) is common and disabling, but its neuropathophysiology
remains unclear. Most studies of functional brain networks in MDD have had limited …