Abstract 'Glomerulonephritis'(GN) is a term used to describe a group of heterogeneous
immune-mediated disorders characterized by inflammation of the filtration units of the kidney …

Proteasome is a multi-subunit protein degradation machine, which plays a key role in the
maintenance of protein homeostasis and, through degradation of regulatory proteins, in the …

Inhibitors of the proteolytic activity of the 20S proteasome have transformed the treatment of
multiple B-cell malignancies. These agents have also been employed with success in the …

Electroreductive ring-opening carboxylation of cycloketone oxime esters with atmospheric
carbon dioxide is reported. This reaction proceeded under simple constant current …

Pharmacologic targeting of chromatin-associated protein complexes has shown significant
responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance …

Cell-mediated immunity is driven by antigenic peptide presentation on major
histocompatibility complex (MHC) molecules. Specialized proteasome complexes called …

Multiple myeloma (MM), a cancer of plasma cells, is the second most common
hematological malignancy which is characterized by aberrant plasma cells infiltration in the …

The immunoproteasome is a specialized form of proteasome equipped with modified
catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen …

Simple Summary Immunoproteasome plays a key role in the generation of antigenic
peptides. Immune checkpoints therapy is a front-line treatment of advanced/metastatic …

At the heart of the ubiquitin–proteasome system, the 20S proteasome core particle (CP)
breaks down the majority of intracellular proteins tagged for destruction. Thereby, the CP …