The first examples of ataxia telangiectasia and Rad3-related (ATR) PROTACs were
designed and synthesized. Among them, the most potent degrader, ZS-7, demonstrated …

Recent studies demonstrate that modified thalidomide chemically alters the binding surface
of its binding E3 ligase, CRBN, leading to the degradation of new substrate proteins. In this …

Proteolysis‐targeting chimeras (PROTACs) is a targeted protein degradation (TPD)
technique effected by hijacking the ubiquitin‐proteasome system (UPS) of the cells. A …

Proteolysis‐targeting chimeras (PROTACs) are essential bifunctional molecules that target
proteins of interest (POIs) for degradation by cellular ubiquitination machinery. Despite …

BCL‐2, a member of the BCL‐2 protein family, is an antiapoptotic factor that regulates the
intrinsic pathway of apoptosis. Due to its aberrant activity, it is frequently implicated in …

Bladder cancer is a common urinary cancer that still lacks effective treatments. In the present
study, we evaluated the effect of BET inhibitor, mivebresib, in combination with PZ703b, a …

There is great demand for the development of novel efficient therapeutic strategies or
preventative measures to alleviate the life-threatening complications of type 2 diabetes …

Proteolysis targeting chimeras (PROTACs) are heterobifunctional ligands that promote
targeted protein degradation (TPD) by reprogramming E3 ubiquitin ligase activity. By affixing …

Abstract Mantle Cell Lymphoma (MCL) is a B cell lymphoma distinguished from other B cell
lymphomas by at (11; 14)(q13: q32) translocation juxtaposing the CCND1 gene downstream …

HDAC3 and HDAC8 have critical biological functions and represent highly sought-after
therapeutic targets. Because histone deacetylases (HDACs) have a very conserved catalytic …