Advances in Preclinical Mantle Cell Lymphoma Research: A Novel Combination Regimen and a Novel Mouse Model

FD Brown - 2023 - rave.ohiolink.edu
Abstract Mantle Cell Lymphoma (MCL) is a B cell lymphoma distinguished from other B cell
lymphomas by at (11; 14)(q13: q32) translocation juxtaposing the CCND1 gene downstream …

PROTACs–A Novel and Rapidly Developing Field of Targeted Protein Degradation

HR Gatley - 2023 - scholarscompass.vcu.edu
There is a continued need for new technology and strategies for tackling cancer and other
diseases, and within the current century a novel therapeutic strategy has emerged in the …

HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation

Y Xiao, S Hale, N Awasthee, C Meng, X Zhang… - Cell chemical …, 2023 - cell.com
HDAC3 and HDAC8 have critical biological functions and represent highly sought-after
therapeutic targets. Because histone deacetylases (HDACs) have a very conserved catalytic …

[PDF][PDF] Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics

J Thorsson - lup.lub.lu.se
Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by
epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with …