Mechanisms of oxidative stress in metabolic syndrome

SK Masenga, LS Kabwe, M Chakulya… - International journal of …, 2023 - mdpi.com
Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus
type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to …

The FOXO family of transcription factors: key molecular players in gastric cancer

Y Liu, X Ao, Y Jia, X Li, Y Wang, J Wang - Journal of Molecular Medicine, 2022 - Springer
Gastric cancer (GC) is the fifth most frequently diagnosed cancer worldwide and the third
leading cause of cancer-related death with an oncological origin. Despite its decline in …

Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia

A Campeau, RH Mills, T Stevens, LA Rossitto… - Molecular …, 2022 - nature.com
Schizophrenia is a devastating psychiatric illness that detrimentally affects a significant
portion of the worldwide population. Aging of schizophrenia patients is associated with …

[HTML][HTML] An overview of glycosylation and its impact on cardiovascular health and disease

KJ Loaeza-Reyes, E Zenteno… - Frontiers in molecular …, 2021 - frontiersin.org
The cardiovascular system is a complex and well-organized system in which glycosylation
plays a vital role. The heart and vascular wall cells are constituted by an array of specific …

Roles of protein post-translational modifications in glucose and lipid metabolism: mechanisms and perspectives

YH Yang, R Wen, N Yang, TN Zhang, CF Liu - Molecular medicine, 2023 - Springer
The metabolism of glucose and lipids is essential for energy production in the body, and
dysregulation of the metabolic pathways of these molecules is implicated in various acute …

Mannose receptor deficiency impacts bone marrow and circulating immune cells during high fat diet induced obesity

J Nour, A Moregola, M Svecla, L Da Dalt, R Bellini… - Metabolites, 2022 - mdpi.com
The mannose receptor C-type 1 (Mrc1) is a C-type lectin receptor expressed on the immune
cells and sinusoidal endothelial cells (ECs) of several tissues, including the bone marrow …

Impact of asialoglycoprotein receptor and mannose receptor deficiency on murine plasma N-glycome profiles

M Svecla, J Nour, MR Bladergroen, S Nicolardi… - Molecular & Cellular …, 2023 - ASBMB
The asialoglycoprotein receptor (ASGPR) and the mannose receptor C-type 1 (MRC1) are
well known for their selective recognition and clearance of circulating glycoproteins …

[HTML][HTML] The role of protein glycosylation in the occurrence and outcome of acute ischemic stroke

J Li, Y Qiu, C Zhang, H Wang, R Bi, Y Wei, Y Li… - Pharmacological …, 2023 - Elsevier
Acute ischemic stroke (AIS) is a serious and life-threatening disease worldwide. Despite
thrombolysis or endovascular thrombectomy, a sizeable fraction of patients with AIS have …

Exploring apolipoprotein C-III: pathophysiological and pharmacological relevance

CJ Packard, A Pirillo, S Tsimikas… - Cardiovascular …, 2023 - academic.oup.com
The availability of pharmacological approaches able to effectively reduce circulating LDL
cholesterol (LDL-C) has led to a substantial reduction in the risk of atherosclerosis-related …

FoxO3 and oxidative stress: a multifaceted role in cellular adaptation

VS Bernardo, FF Torres, DGH Da Silva - Journal of Molecular Medicine, 2023 - Springer
Oxidative stress is a major cause of morbidity and mortality in human health and disease. In
this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively …