Iron accumulates in human atherosclerotic lesions but whether it is a cause or simply a
downstream consequence of the atheroma formation has been an open question for …

Elastic and muscular arteries differ in structure, function, and mechanical properties, and
may adapt differently to aging. We compared the descending thoracic aortas (TA) and the …

Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a
proliferative cell phenotype significantly contributes to the development of atherosclerosis …

Objective—Periostin is a secreted protein that can alter extracellular matrix remodeling in
response to tissue injury. However, the functional role of periostin in the development of …

Healthy human arteries are composed of three layers: the intima, the media, and the
adventitia. Endothelial cells, which form the tunica intima, provide the physical interface …

Mechanisms underlying the rupture of atherosclerotic plaque, a crucial factor in the
development of myocardial infarction and stroke, are not well defined. Here, we examined …

This work shows that an overload of dietary cholesterol causes complete infertility in
dyslipidemic male mice (the Liver X Receptor-deficient mouse model). Infertility resulted …

Tristetraprolin (TTP), an mRNA binding and decaying protein, plays a significant role in
controlling inflammation by decaying mRNAs encoding inflammatory cytokines such as …

Atherosclerosis is one of the main causes of cardiovascular diseases. Our previous study
indicated that a type of peroxidase derived from foxtail millet bran (FMBP) had prominent …

Cyclophilin A (CypA) is a ubiquitously distributed protein present both in intracellular and
extracellular spaces. In atherosclerosis, various cells, including endothelial cells …