Osteoarthritis (OA) has been a leading cause of disability in the elderly and there remains a
lack of effective therapeutic approaches as the mechanisms of pathogenesis and …

Background Osteoarthritis (OA) is a common chronic joint disease, but the association
between molecular and cellular events and the pathogenic process of OA remains unclear …

Dedifferentiation of chondrocyte greatly restricts its function and application, however, it is
poorly understood except a small number of canonical markers. The non-cell-adhesive …

Osteoarthritis (OA) is a leading cause of pain and disability worldwide in elderly people.
There is a critical need to develop novel therapeutic strategies that can effectively manage …

Background N6-methyladenosine (m6A), the most abundant chemical modification on
eukaryotic messenger RNA (mRNA), is modulated by three class of regulators namely …

Background T-2 toxin is thought to induce the growth plate and articular cartilage damage of
Kashin-Beck disease (KBD), an endemic osteochondropathy in China. This study aims to …

Sex differences have been suggested to play critical roles in the pathophysiology of
osteoarthritis (OA), resulting in sex‐specific prevalence and incidence. However, their roles …

Osteoarthritis is a progressive disease characterized by cartilage destruction in the joints.
Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with …

Genetics and epigenetics are important subjects in the field of osteoarthritis (OA) research.
DNA methylation may affect gene transcription, but the specific mechanisms have remained …

Monozygotic twins are genetically identical but rarely phenotypically identical. Epigenetic
and transcriptional variation could influence this phenotypic discordance. Investigation of …