Inadequacies in current therapies for atrial fibrillation have made new drug development
crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia. In …

Amiodarone-induced thyroid dysfunction occurs in 15–20% of amiodarone-treated patients.
Amiodarone-induced hypothyroidism (AIH) does not pose relevant problems, is easily …

Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress
responses, but its role in lung fibrosis is unknown. Here we found that the activity and …

Assessment of TSH and TPO-Ab before starting amiodarone (AM) treatment is
recommended. The usefulness of periodic TSH measurement every 6 months during AM …

A stable luciferase reporter gene assay was developed based on the thyroid hormone
responsive rat pituitary tumor GH3 cell line that constitutively expresses both thyroid …

The initial identification of thyroid hormone receptors (TRs1) was based on binding studies
(Oppenheimer et al., 1972). The TR main ligand is 3, 5, 3!-triiodo-L-thyronine (T3). T3 …

Dronedarone is a noniodinated benzofuran derivative that has been developed to overcome
the limiting iodine‐associated adverse effects of the commonly used antiarrhythmic drug …

Since BRCA1 associated breast cancers are frequently classified as hormone receptor
negative or even triple negative, the application of endocrine therapies is rather limited in …

Amiodarone and dronedarone are two clinically important benzofuran derivatives.
Amiodarone has been used widely for treating resistant tachyarrhythmias in the past three …

Thyroid hormones play a critical role in the growth and development of the alimentary tract in
vertebrates. Their effects are mediated by nuclear receptors as well as the cell surface …