[HTML][HTML] Natural compounds improve diabetic nephropathy by regulating the TLR4 signaling pathway

J Wu, K Li, M Zhou, H Gao, W Wang, W Xiao - Journal of Pharmaceutical …, 2024 - Elsevier
Diabetic nephropathy (DN), a severe complication of diabetes, is widely recognized as a
primary contributor to end-stage renal disease. Recent studies indicate that the inflammation …

Antioxidant, antiapoptotic, and anti-inflammatory effects of hesperetin in a mouse model of lipopolysaccharide-induced acute kidney injury

AY Yang, HJ Choi, K Kim, J Leem - Molecules, 2023 - mdpi.com
Sepsis is a severe inflammatory condition that can cause organ dysfunction, including acute
kidney injury (AKI). Hesperetin is a flavonoid aglycone that has potent antioxidant and anti …

Protective effects of carnosol on renal interstitial fibrosis in a murine model of unilateral ureteral obstruction

JH Park, J Leem, SJ Lee - Antioxidants, 2022 - mdpi.com
Renal fibrosis is a common feature of chronic kidney disease and is a promising therapeutic
target. However, there is still limited treatment for renal fibrosis, so the development of new …

Protective effects of orexin a in a murine model of cisplatin-induced acute kidney injury

J Jo, JY Kim, J Leem - Journal of Clinical Medicine, 2022 - mdpi.com
Cisplatin is a chemotherapeutic agent widely used in the treatment of various cancers, but its
application is often limited due to complications such as acute kidney injury (AKI). Orexins …

Artesunate-nanoliposome-TPP, a novel drug delivery system that targets the mitochondria, attenuates cisplatin-induced acute kidney injury by suppressing oxidative …

J Zhang, L Gu, Y Jiang, Y Ma, Z Zhang… - International Journal …, 2024 - Taylor & Francis
Background Acute kidney injury (AKI) is a syndrome, posing a substantial healthcare
burden. The pathological basis of AKI is associated with inflammation and oxidative stress …

Trilobatin, an Active Dihydrochalcone from Lithocarpus polystachyus, Prevents Cisplatin-Induced Nephrotoxicity via Mitogen-Activated Protein Kinase Pathway …

Y Duan, X Mi, W Su, S Tang, S Jiang, Z Wang… - ACS …, 2022 - ACS Publications
Although naturally occurring flavonoids have shown beneficial effects on the side effects
caused by cisplatin, there are few reports on the protective effect of dihydrochalcone on the …

Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney

BM ALRashdi, RA Mohamed, AH Mohamed… - Bioscience …, 2023 - portlandpress.com
Cisplatin (CDDP) is a commonly prescribed chemotherapeutic agent; however, its
associated nephrotoxicity limits its clinical efficacy and sometimes requires discontinuation …

Structural Analysis and Antioxidant and Immunoregulatory Activities of an Exopolysaccharide Isolated from Bifidobacterium longum subsp. longum XZ01

X Zhang, J Gong, W Huang, W Liu, C Ma, R Liang… - Molecules, 2023 - mdpi.com
Bifidobacterium longum subsp. longum XZ01 (BLSL1) is a new strain (isolated from the
intestines of healthy people and deposited with the preservation number GDMCC 61618) …

Inhibition of ALDOA‐and ENO1‐Mediated Glycolysis of Oridonin as a Novel Antitumor Strategy of Non‐Small‐Cell Lung Cancer

T Lu, Q Wang, M Zhao, L Chen, C Dai… - Advanced …, 2024 - Wiley Online Library
Non‐small‐cell lung cancer (NSCLC) is the most common type of lung cancer. Oridonin
(ORI), the main pharmacodynamic component of the Chinese herb Herba Rabdosiae with …

[HTML][HTML] An iron-based metal-organic framework nanoplatform for enhanced ferroptosis and oridonin delivery as a comprehensive antitumor strategy

M Cai, T Fu, R Zhu, P Hu, J Kong, S Liao, Y Du… - … Pharmaceutica Sinica B, 2024 - Elsevier
Ferroptosis is a recently discovered pathway for regulated cell death pathway. However, its
efficacy is affected by limited iron content and intracellular ion homeostasis. Here, we …