Abstract Silent information regulator 1 (SIRT1) is a ubiquitously expressed protein and has
an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a …

Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD+
as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene …

The use of polyphenols as adjuvants in lowering risk factors for various debilitating diseases
has been investigated in recent years due to their possible antioxidant action. Polyphenols …

Neurodegenerative disorders affect around one billion people worldwide. They can arise
from a combination of genomic, epigenomic, metabolic, and environmental factors. Aging is …

Effective metabolism is highly dependent on a narrow therapeutic range of oxygen.
Accordingly, low levels of oxygen, or hypoxia, are one of the most powerful inducers of gene …

In addition to the traditional treatments of cancer and cancer prevention, the use of natural
compounds, especially those found in food, should be considered. To clarify if resveratrol …

Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of
nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic …

Covering: up to 2020 The National Cancer Institute of the United States (NCI) has initiated a
Cancer Moonshot program entitled the NCI Program for Natural Product Discovery. As part …

Metabolic syndrome (MetS) is a clinical manifestation characterized by a plethora of
comorbidities, including hyperglycemia, abdominal obesity, arterial hypertension, and …

The coronavirus disease 2019 (COVID-19) pandemic continues to burden healthcare
systems worldwide. COVID-19 symptoms are highly heterogeneous, and the patient may be …