[HTML][HTML] Substance Addiction Rehabilitation Drugs

S Yuan, SC Jiang, ZW Zhang, ZL Li, J Hu - Pharmaceuticals, 2024 - mdpi.com
The relapse rate of substance abusers is high, and addiction rehabilitation adjunct drugs
need to be developed urgently. There have been numerous reports on blocking the …

Neuroplasticity-related genes correlate with individual differences in distinct phases of oxycodone self-administration in male rats

FM Vassoler, KE Budge, SB Isgate, KR Gildawie… - …, 2024 - Elsevier
Opioid use disorder (OUD) is a chronic condition associated with long-lasting molecular and
behavioral changes. Animals with prolonged access to opioids develop behaviors similar to …

[HTML][HTML] Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic

A Filošević Vujnović, I Stanković Matić… - Future …, 2024 - mdpi.com
Addiction is a complex brain disease influenced by genetic, environmental, and neurological
factors. Psychostimulants, cocaine, and methamphetamine influence different cell types in …

LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Brain Organoids

MN Costa, L Goto-Silva, JM Nascimento, I Domith… - bioRxiv, 2024 - biorxiv.org
The effects of psychedelics encompass modulation of subjective experience, neuronal
plasticity, brain activity and connectivity, constituting a complex phenomenon. Underlying …

Ameliorating effects of low-dose ketamine administrations on opioid-induced memory impairments and neurodegeneration in mice

E Uyar, U Seker, O Ozhan, MB Acikgul, M Colak… - 2023 - annalsmedres.org
Aim: Opioids have indispensable roles in pain management. A strong link exists between
opioid use and memory impairments, mainly with continuous use. This study investigated …