Gut microbiota, a collection of microorganisms that live within gastrointestinal tract, provides
crucial signaling metabolites for the physiological of hosts. In healthy state, gut microbiota …

Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

Genome mining of biosynthetic pathways with no identifiable core enzymes can lead to
discovery of the so-called unknown (biosynthetic route)–unknown (molecular structure) …

Natural products (NPs) are critical sources of drug molecules for decades. About two-thirds
of natural antibiotics are produced by Streptomyces. Streptomyces have a large number of …

Highlights•Natural products offer a broad chemical catalog for bio-based product
development.•Genome mining tools for identifying BGCs.•Isoprenoid, nonribosomal peptide …

Heterologous expression of biosynthetic gene clusters (BGCs) avails yield improvements
and mining of natural products, but it is limited by lacking of more efficient Gram-negative …

Natural products derived from microbes are crucial innovations that would help in reaching
sustainability development goals worldwide while achieving bioeconomic growth …

Lanthipeptides are ribosomally synthesized and post-translationally modified peptides that
are generated from precursor peptides through a dehydration and cyclization process …

Micrococcus luteus, also known as M. luteus, is a bacterium that inhabits mucous
membranes, human skin, and various environmental sources. It is commonly linked to …

Major advances in genome sequencing and large-scale biosynthetic gene cluster (BGC)
analysis have prompted an age of natural product discovery driven by genome mining. Still …