This book presents a completely novel approach to the understanding of ageing, which
many believe is an unsolved problem in biology. It explains why ageing exists in animals …

Background: Despite more than 60 years of research in the role of serotonin (5-HT) in
psychopathology, many questions still remain. From a developmental perspective, studies …

DNA melting is rate-limiting for cytosine deamination, from which we infer that the rate of
cytosine deamination should decline twofold for each 10% increase in GC content. Analysis …

The functioning of the hypothalamic–pituitary–adrenal (HPA) axis and serotonergic (5-HT)
system are known to be intertwined with mood. Alterations in these systems are often …

Undernutrition during pregnancy is implicated in the programming of offspring for the
development of obesity and diabetes. We hypothesized that maternal programming causes …

Stress responses are largely conserved in eukaryotic cells, but with plants having certain
distinctive reactions to specific stresses, eg the induction of pathogenesis-related proteins …

The molecular mechanisms introducing epigenetic modifications that lead to differential
silencing of some autosomal alleles depending on their parental legacy are still largely …

The germ cell lineages are among the best characterized of all cell lineages in mammals.
This characterization includes precise nomenclature that distinguishes among numerous …

Major depressive disorder of the mother affects 6 to 17% of pregnancies worldwide and can
lead to negative outcomes, such as preterm delivery and later mental health problems of the …

Developments in molecular biology over the past three decades have led to an increasing
awareness of the importance of epigenetic phenomena in a variety of genome functions …