Vertebrate DNA is modified by methyl moieties at the 5′-position of cytosine rings residing
in the di-nucleotide sequence CpG. Approximately 80% of CpG dinucleotide sequences are …

The mechanisms that establish DNA methylation in eukaryotes are poorly understood. In
principle, methylation in a particular chromosomal region may reflect the presence of a …

Regulation of gene expression without changing the DNA sequence is governed by
epigenetic mechanisms. Epigenetic regulation is important for changing chromatin structure …

The methylation of DNA helps stabilize chromatin in an inactive configuration and inhibits
gene transcription. This mechanism of gene regulation is involved in essential genetic …

Tissue-and gene-specific patterns of cytosine-DNA methylation are characteristic features of
vertebrate genomes. The generation and proper maintenance of DNA methylation patterns …

In situ immunofluorescence detection of antibodies against 5-methylcytosine on metaphase
chromosomes prepared by a new procedure allows the display of new 5-methylcytosine-rich …

Chromatin structure is dynamically modulated by various chromatin modifications, such as
histone/DNA methylation and demethylation. We have reviewed histone methyltransferases …

Over the past decade, epigenetic analyses have made important contributions to our
understanding of healthy development and a wide variety of adverse conditions such as …

Three different kinds of alterations in DNA methylation have been observed in urological
malignancies. DNA hypermethylation of CpG-rich promoter regions is an important …

This article presents localization of cytosine-5 DNA methyltransferases Dnmt3a and
Dnmt3bto mouse chromosome bands 12A2-A3 and 2H1 by in situ hybridization. The …