Molecular pathogenesis and mechanisms of thyroid cancer
M Xing - Nature Reviews Cancer, 2013 - nature.com
Thyroid cancer is a common endocrine malignancy. There has been exciting progress in
understanding its molecular pathogenesis in recent years, as best exemplified by the …
understanding its molecular pathogenesis in recent years, as best exemplified by the …
BRAF mutation in papillary thyroid cancer and its value in tailoring initial treatment: a systematic review and meta-analysis
Clinicians have long sought to characterize biological markers of neoplasia as objective
indicators of tumor presence, pathogenicity, and prognosis. Armed with data that correlate …
indicators of tumor presence, pathogenicity, and prognosis. Armed with data that correlate …
The Prognostic Value of BRAF Mutation in Colorectal Cancer and Melanoma: A Systematic Review and Meta-Analysis
Background Mutation of BRAF is a predominant event in cancers with poor prognosis such
as melanoma and colorectal cancer. BRAF mutation leads to a constitutive activation of …
as melanoma and colorectal cancer. BRAF mutation leads to a constitutive activation of …
[HTML][HTML] Anaplastic thyroid cancer: molecular pathogenesis and emerging therapies
RC Smallridge, LA Marlow… - Endocrine-related …, 2009 - erc.bioscientifica.com
Anaplastic thyroid cancer (ATC) is a rare malignancy. While external beam radiation therapy
has improved locoregional control, the median survival of∼ 4 months has not changed in …
has improved locoregional control, the median survival of∼ 4 months has not changed in …
Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer
M Xing - Thyroid, 2010 - liebertpub.com
Background: Aberrant activation of the phosphatidylinositol-3 kinase (PI3K)/Akt pathway
plays a fundamental role in thyroid tumorigenesis, particularly in follicular thyroid cancer …
plays a fundamental role in thyroid tumorigenesis, particularly in follicular thyroid cancer …
Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review
X Liao, T Morikawa, P Lochhead, Y Imamura… - Clinical cancer …, 2012 - AACR
Abstract Purpose: Mutations in PIK3CA [the gene encoding the p110α catalytic subunit of
phosphatidylinositide-3-kinase (PI3K)] play an important role in colorectal carcinogenesis …
phosphatidylinositide-3-kinase (PI3K)] play an important role in colorectal carcinogenesis …
[图书][B] Diagnostic pathology and molecular genetics of the thyroid: a comprehensive guide for practicing thyroid pathology
YE Nikiforov, PW Biddinger, LDR Thompson - 2012 - books.google.com
Diagnostic Pathology and Molecular Genetics of the Thyroid, Second Edition, offers a
comprehensive overview of the diagnostic surgical pathology, cytopathology …
comprehensive overview of the diagnostic surgical pathology, cytopathology …
Molecular pathology of thyroid tumours of follicular cells: a review of genetic alterations and their clinicopathological relevance
G Acquaviva, M Visani, A Repaci, KJ Rhoden… - …, 2018 - Wiley Online Library
Thyroid cancer is the most common endocrine malignancy. Knowledge of the molecular
pathology of thyroid tumours originating from follicular cells has greatly advanced in the past …
pathology of thyroid tumours originating from follicular cells has greatly advanced in the past …
Acquired Secondary RAS Mutation in BRAFV600E-Mutated Thyroid Cancer Patients Treated with BRAF Inhibitors
ME Cabanillas, R Dadu, P Iyer, KB Wanland… - Thyroid, 2020 - liebertpub.com
Background: The BRAFV600E mutation is the most common driver mutation in papillary
thyroid cancer (PTC) and anaplastic thyroid cancer (ATC). This mutation is considered …
thyroid cancer (PTC) and anaplastic thyroid cancer (ATC). This mutation is considered …
V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours
A Agaimy, LM Terracciano, S Dirnhofer… - Journal of clinical …, 2009 - jcp.bmj.com
Background: A small subset (10–15%) of gastrointestinal stromal tumours (GISTs) lack
mutations in KIT and PDGFRA (wild-type GIST). Recently, a novel BRAF exon 15 mutation …
mutations in KIT and PDGFRA (wild-type GIST). Recently, a novel BRAF exon 15 mutation …