The serotonergic pathways originating in the dorsal and median raphe nuclei (DR and MnR,
respectively) are critically involved in cortical function. Serotonin (5-HT), acting on …

Higher-order executive tasks such as learning, working memory, and behavioral flexibility
depend on the prefrontal cortex (PFC), the brain region most elaborated in primates. The …

The 5-HT1A receptor is highly expressed both in 5-HT neurons as a presynaptic inhibitory
autoreceptor, and in many brain regions innervated by 5-HT as a post-synaptic …

Objective Topiramate, valproate, propranolol, amitriptyline, and methysergide have been
widely prescribed for migraine prophylaxis, but their mechanism or site of action is uncertain …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Abstract Serotonergic 5-HT1A and 5-HT2A receptors are abundantly expressed in prefrontal
cortex (PFC) and are targets of atypical antipsychotic drugs. They mediate, respectively …

Atypical antipsychotics increase dopamine (DA) release in the medial prefrontal cortex
(mPFC), an effect possibly involved in the superior effects of atypical versus classical …

Serotonin is involved in psychiatric disorders exhibiting abnormal prefrontal cortex (PFC)
function (eg major depression, schizophrenia). We examined the effect of the stimulation of …

Rationale There is increasing interest in antipsychotics intended to manage positive
symptoms via D 2 receptor blockade and improve negative symptoms and cognitive deficits …

Adaptive, goal-directed behavior requires that organisms evaluate their actions in terms of
their outcomes. Neuroimaging studies show that unfavorable outcomes or situations with …