Quantitative computed tomography in COPD: possibilities and limitations

OM Mets, PA De Jong, B Van Ginneken, HA Gietema… - Lung, 2012 - Springer
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease that is
characterized by chronic airflow limitation. Unraveling of this heterogeneity is challenging …

Recent advances in computed tomography imaging in chronic obstructive pulmonary disease

S Bodduluri, JM Reinhardt, EA Hoffman… - Annals of the …, 2018 - atsjournals.org
Lung imaging is increasingly being used to diagnose, quantify, and phenotype chronic
obstructive pulmonary disease (COPD). Although spirometry is the gold standard for the …

Circulating endothelial microparticles as a measure of early lung destruction in cigarette smokers

C Gordon, K Gudi, A Krause, R Sackrowitz… - American journal of …, 2011 - atsjournals.org
Rationale: There is increasing evidence that emphysema is associated with primary loss of
pulmonary capillary endothelium. Plasma levels of endothelial microparticles (EMPs), small …

Endoscopic lung volume reduction: an expert panel recommendation-update 2017

FJF Herth, DJ Slebos, GJ Criner, PL Shah - Respiration, 2017 - karger.com
Interest in endoscopic lung volume reduction (ELVR) technologies for emphysema is
consistently growing. In the last couple of months, several endoscopic options (eg, endo-or …

The future of chronic obstructive pulmonary disease treatment—difficulties of and barriers to drug development

FJ Martinez, JF Donohue, SI Rennard - The Lancet, 2011 - thelancet.com
Although chronic obstructive pulmonary disease (COPD) is a major global health problem
with a rising incidence and morbidity, few pharmacotherapeutic advances have been made …

Spatial patterns and frequency distributions of regional deformation in the healthy human lung

DE Hurtado, N Villarroel, C Andrade, J Retamal… - … and modeling in …, 2017 - Springer
Understanding regional deformation in the lung has long attracted the medical community,
as parenchymal deformation plays a key role in respiratory physiology. Recent advances in …

Investigation of four-dimensional computed tomography-based pulmonary ventilation imaging in patients with emphysematous lung regions

T Yamamoto, S Kabus, T Klinder… - Physics in Medicine …, 2011 - iopscience.iop.org
A pulmonary ventilation imaging technique based on four-dimensional (4D) computed
tomography (CT) has advantages over existing techniques. However, physiologically …

Registration-based lung mechanical analysis of chronic obstructive pulmonary disease (COPD) using a supervised machine learning framework

S Bodduluri, JD Newell Jr, EA Hoffman, JM Reinhardt - Academic radiology, 2013 - Elsevier
RATIONALE AND OBJECTIVES: This study evaluated the performance of computed
tomography (CT)-derived biomechanical based features of lung function and the presence …

Endoscopic lung volume reduction: an expert panel recommendation

FJF Herth, DJ Slebos, KF Rabe, PL Shah - Respiration, 2016 - karger.com
Chronic obstructive pulmonary disease (COPD) is a progressive condition comprising a
constellation of disorders from chronic bronchitis, airflow obstruction through to emphysema …

Normal range of emphysema and air trapping on CT in young men

OM Mets, RA van Hulst, C Jacobs… - American Journal of …, 2012 - Am Roentgen Ray Soc
OBJECTIVE. The purpose of our study was to assess the normal range of CT measures of
emphysema and air trapping in young men with normal lung function. MATERIALS AND …