Oxidative stress results from the disruption of the redox system marked by a notable
overproduction of reactive oxygen species. There are four major sources of reactive oxygen …

Despite marked improvements in the survival of patients with severe lupus nephritis over the
past 50 years, the rate of complete clinical remission after immune suppression therapy is< …

Atypical hemolytic uremic syndrome (aHUS) is a rare, possibly life-threatening disease
characterized by platelet activation, hemolysis and thrombotic microangiopathy (TMA) …

Complex multicellular life in mammals relies on functional cooperation of different organs for
the survival of the whole organism. The kidneys play a critical part in this process through …

Epidemiologic, clinical, and molecular evidence suggest that aging is a major contributor to
the increasing incidence of acute kidney injury and chronic kidney disease. The aging …

Objective: Reduction in capillary density or rarefaction is a hallmark of essential
hypertension. We measured the retinal capillary density using noninvasive optical …

Kidney fibrosis is the final common pathway of virtually all chronic kidney diseases (CKDs)
and is therefore considered to be a promising therapeutic target for these conditions …

Chronic kidney disease (CKD) will progress to end stage without treatment, but the decline
of renal function may not be linear. Compared with glomerular filtration rate and proteinuria …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are rising in global prevalence
and cause significant morbidity for patients. Current treatments are limited to slowing instead …

The kidney is permeated by a highly complex vascular system with glomerular and
peritubular capillary networks that are essential for maintaining the normal functions of …