[PDF][PDF] Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR inhibitors
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …
Autocrine, paracrine and juxtacrine signaling by EGFR ligands
Receptor and cytoplasmic protein tyrosine kinases play prominent roles in the control of a
range of cellular processes during embryonic development and in the regulation of many …
range of cellular processes during embryonic development and in the regulation of many …
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway
HW Lo, SC Hsu, M Ali-Seyed, M Gunduz, W Xia, Y Wei… - Cancer cell, 2005 - cell.com
Epidermal growth factor receptor (EGFR) exists in the nucleus of highly proliferative cells
where it functions as a transcription factor. Although EGFR has transactivational activity, it …
where it functions as a transcription factor. Although EGFR has transactivational activity, it …
Dysregulation of growth factor signaling in human hepatocellular carcinoma
K Breuhahn, T Longerich, P Schirmacher - Oncogene, 2006 - nature.com
Dysregulation of pleiotropic growth factors, receptors and their downstream signaling
pathway components represent a central protumorigenic principle in human …
pathway components represent a central protumorigenic principle in human …
Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: variation in staining intensity due to choice of fixative and storage time of tissue sections
D Atkins, KA Reiffen, CL Tegtmeier… - … of Histochemistry & …, 2004 - journals.sagepub.com
The epidermal growth factor receptor (EGFR) is highly expressed in a variety of solid
malignant tumors and its expression has been correlated with disease progression and poor …
malignant tumors and its expression has been correlated with disease progression and poor …
Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors
The development of therapeutic inhibitors of key signaling pathways has been hampered by
the inability to assess the effect of a drug on its target in the patient. 17 …
the inability to assess the effect of a drug on its target in the patient. 17 …
Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR) combining anti-EGFR antibody with tyrosine kinase inhibitor
S Huang, EA Armstrong, S Benavente, P Chinnaiyan… - Cancer research, 2004 - AACR
Molecular inhibition of epidermal growth factor receptor (EGFR/HER1) signaling is under
active investigation as a promising cancer treatment strategy. We examined the potency of …
active investigation as a promising cancer treatment strategy. We examined the potency of …
Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody
Purpose Cetuximab, a chimeric monoclonal antibody targeting epidermal growth factor
receptor (EGFR) on the surface of cancer cells, was approved by the FDA to treat patients …
receptor (EGFR) on the surface of cancer cells, was approved by the FDA to treat patients …
The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications
M Zimmermann, A Zouhair, D Azria, M Ozsahin - Radiation oncology, 2006 - Springer
Epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptors. Its
stimulation by endogenous ligands, EGF or transforming growth factor-alpha (TGF-α) results …
stimulation by endogenous ligands, EGF or transforming growth factor-alpha (TGF-α) results …
EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization
HW Lo, SC Hsu, MC Hung - Breast cancer research and treatment, 2006 - Springer
Aberrant epidermal growth factor receptor (EGFR) signaling is a major characteristic of many
human malignancies including breast cancer. Since the discovery of EGF in 1960's and its …
human malignancies including breast cancer. Since the discovery of EGF in 1960's and its …