Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

The incidence of cardiac failure and chronic renal failure is increasing and it has now
become clear that the co-existence of the two problems has an extremely bad prognosis. We …

There is growing evidence that oxidative stress contributes to hypertension. Oxidative stress
can precede the development of hypertension. In almost all models of hypertension, there is …

Nitroxides can undergo one-or two-electron reduction reactions to hydroxylamines or
oxammonium cations, respectively, which themselves are interconvertible, thereby providing …

Loss of redox homeostasis and formation of excessive free radicals play an important role in
the pathogenesis of kidney disease and hypertension. Free radicals such as reactive …

Reactive oxygen species (ROS) are produced by the aerobic metabolism. The imbalance
between production of ROS and antioxidant defence in any cell compartment is associated …

Elevated glomerular filtration rate (GFR) is a common observation in early diabetes mellitus
and closely correlates with the progression of diabetic nephropathy. Hyperfiltration has been …

Oxidative stress implies an increased production of reactive oxygen species (ROS) or a
decreased capacity to metabolize them. Superoxide anion (O) can bioinactivate nitric oxide …

The thick ascending limb plays a key role in maintaining water and electrolyte balance. The
importance of this segment in regulating blood pressure is evidenced by the effect of loop …

Superoxide enhances tubuloglomerular feedback by constricting the afferent arteriole.
Background Superoxide (O 2−) has been shown to augment tubuloglomerular feedback …