Prostate cancer (PCa) is globally the second most diagnosed cancer type and the most
common cause of cancer-related deaths in men. Family history of PCa, hereditary breast …

Pathogenic germline variants underlie up to 20% of ovarian cancer (OC) and are associated
with varying degrees of risk for OC. For mutations in high-penetrance genes such as …

Increased risk for upper tract urothelial carcinoma is described in patients with Lynch
syndrome, caused by germline mutations in mismatch repair genes. We aimed to identify the …

Abstract Study Objective To evaluate characteristics of young women with endometrial
hyperplasia or cancer. Design Retrospective chart review. Setting Tertiary care referral …

Cancer predisposition syndromes are associated with an increased risk of developing
primary malignancies. Here we discuss those which are associated with an increased risk of …

Background The objective of this study was to assess the correlation between mismatch
repair (MMR) status, disease recurrence patterns, and recurrence‐free survival (RFS) in …

Precision medicine aims to individualize care by understanding differences in genetics,
lifestyle, and environment. Pharmacogenomics and cancer genetics represent two …

Abstract Background The prevalence of Lynch syndrome and screening strategies for this
disorder in Chinese patients with endometrial cancer have seldom been investigated. Such …

Lynch syndrome (LS) is an autosomal-dominant inherited disorder mainly caused by a
germline mutation in the DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6, and …

Endometrial cancer (EC) is the fifth most common cancer in women from developed
countries, accounting for 4.8% of new cases and 2.1% of deaths. The genetic basis for the …