Genome-wide association studies of cancer in diverse populations
Genome-wide association studies (GWAS) of cancer have identified more than 700 risk loci,
of which approximately 80% were first discovered in European ancestry populations …
of which approximately 80% were first discovered in European ancestry populations …
European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European
women, but their utility in Asian women is unclear. Here we evaluate the best performing …
women, but their utility in Asian women is unclear. Here we evaluate the best performing …
Breast cancer risk prediction using a clinical risk model and polygenic risk score
Breast cancer risk assessment can inform the use of screening and prevention modalities.
We investigated the performance of the Breast Cancer Surveillance Consortium (BCSC) risk …
We investigated the performance of the Breast Cancer Surveillance Consortium (BCSC) risk …
Systematic identification of regulatory variants associated with cancer risk
S Liu, Y Liu, Q Zhang, J Wu, J Liang, S Yu, GH Wei… - Genome biology, 2017 - Springer
Background Most cancer risk-associated single nucleotide polymorphisms (SNPs) identified
by genome-wide association studies (GWAS) are noncoding and it is challenging to assess …
by genome-wide association studies (GWAS) are noncoding and it is challenging to assess …
Variants of FGFR2 and their associations with breast cancer risk: a HUGE systematic review and meta-analysis
F Cui, D Wu, W Wang, X He, M Wang - Breast cancer research and …, 2016 - Springer
Extensive epidemiological studies have demonstrated that there are associations between
variants in intron 2 of FGFR2 and the breast cancer risk in various populations; however, the …
variants in intron 2 of FGFR2 and the breast cancer risk in various populations; however, the …
A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study
H Nakagawa-Senda, T Hachiya, A Shimizu… - Scientific reports, 2018 - nature.com
Coffee is one of the most widely consumed beverages worldwide, and its role in human
health has received much attention. Although genome-wide association studies (GWASs) …
health has received much attention. Although genome-wide association studies (GWASs) …
Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci
Breast cancer is one of the most common malignancies among women worldwide. Genetic
factors have been shown to play an important role in breast cancer aetiology. We conducted …
factors have been shown to play an important role in breast cancer aetiology. We conducted …
Common matrix metalloproteinase-2 gene variants and altered susceptibility to breast cancer and associated features in Tunisian women
AF Habel, RM Ghali, H Bouaziz, A Daldoul… - Tumor …, 2019 - journals.sagepub.com
A role for matrix metalloproteinase polymorphisms in breast cancer development and
progression was proposed, but with inconclusive results. We assessed the relation of matrix …
progression was proposed, but with inconclusive results. We assessed the relation of matrix …
Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population
Genome-wide association studies (GWAS) have successfully identified about 70 genomic
loci associated with breast cancer. Owing to the complexity of linkage disequilibrium and …
loci associated with breast cancer. Owing to the complexity of linkage disequilibrium and …
Effects of FGFR gene polymorphisms on response and toxicity of cyclophosphamide-epirubicin-docetaxel-based chemotherapy in breast cancer patients
L Chen, H Qi, L Zhang, H Li, J Shao, H Chen, M Zhong… - BMC cancer, 2018 - Springer
Background The chemotherapy resistance and toxicity of chemotherapy are major problems
in breast cancer treatment. However, candidate biomarkers for predicting clinical outcomes …
in breast cancer treatment. However, candidate biomarkers for predicting clinical outcomes …