Human trophoblast stem cell-state acquisition from pluripotent stem cells and somatic cells
M Naama, Y Buganim - Current Opinion in Genetics & Development, 2023 - Elsevier
Highlights•hTSCs can be derived from both primed and naive PSCs.•hTSC-state can be
induced from fibroblasts independently to pluripotency.•Stabilization of the naive TE state in …
induced from fibroblasts independently to pluripotency.•Stabilization of the naive TE state in …
[HTML][HTML] Exploring maternal-fetal interface with in vitro placental and trophoblastic models
X Liu, G Wang, H Huang, X Lv, Y Si, L Bai… - Frontiers in Cell and …, 2023 - ncbi.nlm.nih.gov
The placenta, being a temporary organ, plays a crucial role in facilitating the exchange of
nutrients and gases between the mother and the fetus during pregnancy. Any abnormalities …
nutrients and gases between the mother and the fetus during pregnancy. Any abnormalities …
Modeling embryo-endometrial interface recapitulating human embryo implantation
The initiation of human pregnancy is marked by the implantation of an embryo into the
uterine environment; however, the underlying mechanisms remain largely elusive. To …
uterine environment; however, the underlying mechanisms remain largely elusive. To …
Modeling placental development and disease using human pluripotent stem cells
R Morey, T Bui, KM Fisch, M Horii - Placenta, 2023 - Elsevier
Our current knowledge of the cellular and molecular mechanisms of placental epithelial
cells, trophoblast, primarily came from the use of mouse trophoblast stem cells and tumor …
cells, trophoblast, primarily came from the use of mouse trophoblast stem cells and tumor …
BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment
R Gu, F Dai, C Xiang, J Chen, D Yang, W Tan… - The Journal of Steroid …, 2023 - Elsevier
Polycystic ovary syndrome (PCOS) is a complex reproductive endocrine disease
characterized by ovulation dysfunction with multiple etiologies and manifestations, and it is …
characterized by ovulation dysfunction with multiple etiologies and manifestations, and it is …
[HTML][HTML] Human archetypal pluripotent stem cells differentiate into trophoblast stem cells via endogenous BMP5/7 induction without transitioning through naive state
Primary human trophoblast stem cells (TSCs) and TSCs derived from human pluripotent
stem cells (hPSCs) can potentially model placental processes in vitro. Yet, the pluripotent …
stem cells (hPSCs) can potentially model placental processes in vitro. Yet, the pluripotent …
TGFβ signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy
M Horvat Mercnik, C Schliefsteiner… - Human …, 2024 - academic.oup.com
BACKGROUND The placenta is a unique and pivotal organ in reproduction, controlling
crucial growth and cell differentiation processes that ensure a successful pregnancy …
crucial growth and cell differentiation processes that ensure a successful pregnancy …
Unlocking trophectoderm mysteries: In vivo and in vitro perspectives on human and mouse trophoblast fate induction
M Azagury, Y Buganim - Developmental Cell, 2024 - cell.com
In recent years, the pursuit of inducing the trophoblast stem cell (TSC) state has gained
prominence as a compelling research objective, illuminating the establishment of the …
prominence as a compelling research objective, illuminating the establishment of the …
BMP4 in human endometrial stromal cells can affect decidualization by regulating FOXO1 expression
Y Huang, F Dai, L Chen, Z Li, H Liu, Y Cheng - Endocrinology, 2024 - academic.oup.com
Context Recurrent spontaneous abortion (RSA) is defined as the loss of 2 or more
consecutive intrauterine pregnancies with the same sexual partner in the first trimester …
consecutive intrauterine pregnancies with the same sexual partner in the first trimester …
Early differentiation and gene expression characteristics of trophoblast lineages
J Qin, W Li, B Lv, Z Xue, J Xue - Biology of Reproduction, 2023 - academic.oup.com
With the development of the embryo, the totipotent blastomere undergoes the first lineage
decision to the inner cell mass (ICM) and the trophectoderm (TE). The ICM forms the fetus …
decision to the inner cell mass (ICM) and the trophectoderm (TE). The ICM forms the fetus …