Highlights•hTSCs can be derived from both primed and naive PSCs.•hTSC-state can be
induced from fibroblasts independently to pluripotency.•Stabilization of the naive TE state in …

The placenta, being a temporary organ, plays a crucial role in facilitating the exchange of
nutrients and gases between the mother and the fetus during pregnancy. Any abnormalities …

The initiation of human pregnancy is marked by the implantation of an embryo into the
uterine environment; however, the underlying mechanisms remain largely elusive. To …

Our current knowledge of the cellular and molecular mechanisms of placental epithelial
cells, trophoblast, primarily came from the use of mouse trophoblast stem cells and tumor …

Polycystic ovary syndrome (PCOS) is a complex reproductive endocrine disease
characterized by ovulation dysfunction with multiple etiologies and manifestations, and it is …

Primary human trophoblast stem cells (TSCs) and TSCs derived from human pluripotent
stem cells (hPSCs) can potentially model placental processes in vitro. Yet, the pluripotent …

BACKGROUND The placenta is a unique and pivotal organ in reproduction, controlling
crucial growth and cell differentiation processes that ensure a successful pregnancy …

In recent years, the pursuit of inducing the trophoblast stem cell (TSC) state has gained
prominence as a compelling research objective, illuminating the establishment of the …

Context Recurrent spontaneous abortion (RSA) is defined as the loss of 2 or more
consecutive intrauterine pregnancies with the same sexual partner in the first trimester …

With the development of the embryo, the totipotent blastomere undergoes the first lineage
decision to the inner cell mass (ICM) and the trophectoderm (TE). The ICM forms the fetus …