Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

R Chen, H Zhang, B Tang, Y Luo, Y Yang… - … and Targeted Therapy, 2024 - nature.com
The immune response holds a pivotal role in cardiovascular disease development. As
multifunctional cells of the innate immune system, macrophages play an essential role in …

Therapeutic potential of natural products and underlying targets for the treatment of aortic aneurysm

W Zhao, B Li, J Hao, R Sun, P He, H Lv, M He… - Pharmacology & …, 2024 - Elsevier
Aortic aneurysm is a vascular disease characterized by irreversible vasodilatation that can
lead to dissection and rupture of the aortic aneurysm, a life-threatening condition. Thoracic …

Neutrophil Extracellular Traps in Cardiovascular and Aortic Disease: A Narrative Review on Molecular Mechanisms and Therapeutic Targeting

N Ibrahim, W Eilenberg, C Neumayer… - International Journal of …, 2024 - mdpi.com
Neutrophil extracellular traps (NETs), composed of DNA, histones, and antimicrobial
proteins, are released by neutrophils in response to pathogens but are also recognized for …

CNS-associated macrophages contribute to intracerebral aneurysm pathophysiology

M Glavan, A Jelic, D Levard, J Frösen… - Acta Neuropathologica …, 2024 - Springer
Intracerebral aneurysms (IAs) are pathological dilatations of cerebral arteries whose rupture
leads to subarachnoid hemorrhage, a significant cause of disability and death. Inflammation …

Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice

SJM Stefens, N van Vliet, A IJpma, J Burger, Y Li… - npj Aging, 2024 - nature.com
Aortic aneurysms are dilatations of the aorta that can rupture when left untreated. We used
the aneurysmal Fibulin-4 R/R mouse model to further unravel the underlying mechanisms of …

Identification of biomarkers for abdominal aortic aneurysm in Behçet's disease via mendelian randomization and integrated bioinformatics analyses

C Liu, H Wu, K Li, Y Chi, Z Wu… - Journal of Cellular and …, 2024 - Wiley Online Library
Behçet's disease (BD) is a complex autoimmune disorder impacting several organ systems.
Although the involvement of abdominal aortic aneurysm (AAA) in BD is rare, it can be …

Deciphering the role of CX3CL1-CX3CR1 in aortic aneurysm pathogenesis: insights from Mendelian randomization and transcriptomic analyses

X Qian, Y Zheng, L Xu, Z Liu, M Chen, F Tong… - Frontiers in …, 2024 - frontiersin.org
Background The crucial role of inflammation in aortic aneurysm (AA) is gaining prominence,
while there is still a lack of key cytokines or targets for effective clinical translation. Methods …

Computational fluid dynamics in cardiac surgery and perfusion: A review

C Catalano, F Crascì, S Puleo, R Scuoppo… - …, 2024 - journals.sagepub.com
Cardiovascular diseases persist as a leading cause of mortality and morbidity, despite
significant advances in diagnostic and surgical approaches. Computational Fluid Dynamics …

The Year in Aortic Surgery: Selected Highlights from 2023

RJ Fernando, SR Coleman, F Alghanem… - … of Cardiothoracic and …, 2024 - Elsevier
This article reviews the recent and relevant literature to the field of aortic surgery. The
specific areas that are highlighted include outcomes of Stanford type A dissection …

3D speckle tracking for evaluation of dilative ascending aorta biomechanics: sensitive markers for ascending aorta longitudinal strain predict aortic root dilation rate

D Buioni, P Nardi, C Bassano, C Pisano… - Journal of Surgical …, 2024 - academic.oup.com
Ascending aortic aneurysm is a predisposing condition for rupture and a risk factor for
dissection. In autopsy studies, the prevalence of aortic dissection ranges from 0.2% to 0.8 …