The epithelial Na+ channel (ENaC) and the acid-sensing ion channels (ASICs) form
subfamilies within the ENaC/degenerin family of Na+ channels. ENaC mediates …

Acid‐sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC) are both
members of the ENaC/degenerin family of amiloride‐sensitive Na+ channels. ASICs act as …

Highly viscoelastic and adhesive sputum has precluded efficient nanoparticle-based drug
and gene delivery to the lungs of patients with cystic fibrosis (CF). We sought to determine …

Models of the outer epithelia of the human body-namely the skin, the intestine and the lung-
have found valid applications in both research and industrial settings as attractive …

The cystic fibrosis (CF) lung disease is due to the lack/dysfunction of the CF Transmembrane
Conductance Regulator (CFTR), a chloride channel expressed by epithelial cells as the …

Introduction: Cystic fibrosis is an autosomal recessive disorder caused by mutations in the
cystic fibrosis transmembrane conductance regulator (CFTR) gene that codes for the CFTR …

Channelopathies, defined as diseases that are caused by mutations in genes encoding ion
channels, are associated with a wide variety of symptoms. Impaired chloride transport can …

Bhagawan WS, Suproborini A, Putri DLP, Nurfatma A, Putra RT. 2022. Ethnomedicinal
study, phytochemical characterization, and pharmacological confirmation of selected …

Airway mucus obstruction is a key feature of cystic fibrosis (CF) and chronic obstructive
pulmonary disease (COPD). The thin layer of mucus that covers healthy airway surfaces has …

Mammalian airways are protected from infection by a thin film of airway surface liquid (ASL)
which covers airway epithelial surfaces and acts as a lubricant to keep mucus from adhering …