[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

[HTML][HTML] Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus

MS Burhans, DK Hagman, JN Kuzma… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

Changes in nutritional status impact immune cell metabolism and function

Y Alwarawrah, K Kiernan, NJ MacIver - Frontiers in immunology, 2018 - frontiersin.org
Immune cell function and metabolism are closely linked. Many studies have now clearly
demonstrated that alterations in cellular metabolism influence immune cell function and that …

Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients

Y Jouan, A Guillon, L Gonzalez, Y Perez… - Journal of Experimental …, 2020 - rupress.org
Disclosures: S. Ehrmann reported personal fees from Aerogen, grants from Fisher & Paykel,
grants from Hamilton Medical, and personal fees from La Diffusion Technique Française …

Immune and non-immune functions of adipose tissue leukocytes

WV Trim, L Lynch - Nature Reviews Immunology, 2022 - nature.com
Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence.
Much of the work into understanding the role of immune cells in adipose tissue has been in …

The role of infiltrating immune cells in dysfunctional adipose tissue

TJ Guzik, DS Skiba, RM Touyz… - Cardiovascular …, 2017 - academic.oup.com
Adipose tissue (AT) dysfunction, characterized by loss of its homeostatic functions, is a
hallmark of non-communicable diseases. It is characterized by chronic low-grade …

Tissue immune cells fuel obesity-associated inflammation in adipose tissue and beyond

R Liu, BS Nikolajczyk - Frontiers in immunology, 2019 - frontiersin.org
Obesity-associated inflammation stems from a combination of cell-intrinsic changes of
individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune …

Tissue-specific functions of invariant natural killer T cells

CM Crosby, M Kronenberg - Nature Reviews Immunology, 2018 - nature.com
Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an
invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They …

Regulation of metabolism by the innate immune system

DE Lackey, JM Olefsky - Nature Reviews Endocrinology, 2016 - nature.com
Low-grade tissue inflammation induced by obesity can result in insulin resistance, which in
turn is a key cause of type 2 diabetes mellitus. Cells of the innate immune system produce …

Obesity as a major risk factor for cancer

G De Pergola, F Silvestris - Journal of obesity, 2013 - Wiley Online Library
The number of cancer cases caused by being obese is estimated to be 20% with the
increased risk of malignancies being influenced by diet, weight change, and body fat …