Stephania tetrandra and other related species of Menispermaceae form the major source of
the bisbenzylisoquinoline alkaloid–tetrandrine. The plant is extensively referenced in the …

Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of
K+ ions across the cell membrane along its electrochemical gradient. They regulate the …

Background—Prolongation of action potential duration (APD) is considered a major
antiarrhythmic mechanism (class 2I), but paradoxically, it frequently is also proarrhythmic …

Introduction: RSD1235 is a novel drug recently shown to convert AF rapidly and safely in
patients. 1 Its mechanism of action has been investigated in a rat model of ischemic …

Natural products, containing inherently large-scale structural diversity than synthetic
compounds, have been the major resources of bioactive agents and will continually play as …

There is currently increased interest in the use of the antimalarial drugs chloroquine and
hydroxychloroquine for the treatment of other diseases, including cancer and viral infections …

Voltage-gated ion channels regulate many physiological functions and are targets for a
number of drugs. Patch-clamp electrophysiology is the standard method for measuring …

抄録 A progressively increasing number of cardiac and noncardiac drugs prolong the
ventricular action potential duration (QT interval of the electrocardiogram) and cause a …

The novel T-type antagonist (S)-5 has been prepared and evaluated in in vitro and in vivo
assays for T-type calcium ion channel activity. Structural modification of the piperidine leads …

Cisapride is a prokinetic agent which has been associated with QT prolongation, torsades
de pointes and cardiac arrest. The cellular mechanism for these observations is high affinity …