The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

The urothelium, which lines the renal pelvis, ureters, urinary bladder, and proximal urethra,
forms a high-resistance but adaptable barrier that surveils its mechanochemical …

Transient receptor potential vanilloid 1 (TRPV1) is an ion channel expressed on sensory
neurons triggering an influx of cations. TRPV1 receptors function as homotetramers …

Transient receptor potential vanilloid 1 (TRPV1) is an ion channel present on sensory
neurons which is activated by heat, protons, capsaicin and a variety of endogenous lipids …

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a common chronic pelvic disorder with
sensory symptoms of urinary urgency, frequency, and pain, indicating a key role for …

Sensory nerve fibers innervating the ocular anterior surface detect external stimuli producing
innocuous and painful sensations. Protons are among the first mediators released by …

Lower urinary tract dysfunction (LUTd) represents a major healthcare problem. Although it is
mostly not lethal, associated social disturbance, medical costs, loss of productivity and …

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a type of chronic bladder inflammation
characterized by increased voiding frequency, urgency and pelvic pain. The sensitization of …

Background and Purpose Interstitial cystitis (= painful bladder syndrome) is a chronic
bladder syndrome characterised by pelvic and bladder pain, urinary frequency and urgency …

Urinary tract infections (UTIs) cause bladder hyperactivity and pelvic pain, but the underlying
causes of these symptoms remain unknown. We investigated whether afferent sensitization …