Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

Simple Summary Acquired resistance to molecularly targeted therapies remains a major
challenge in the treatment of cancer. It has been hypothesized that drug-tolerant (or …

The canonical model of RB-mediated tumour suppression developed over the past 30 years
is based on the regulation of E2F transcription factors to restrict cell cycle progression …

Cancer stem cells (CSCs), a minor subpopulation of tumor bulks with self-renewal and
seeding capacity to generate new tumors, posit a significant challenge to develop effective …

Ferroptosis is a novel type of regulated cell death, whose unique metabolic characteristics
are commonly used to evaluate the conditions of various diseases especially in tumors …

Salivary gland acinar cells are routinely destroyed during radiation treatment for head and
neck cancer that results in a lifetime of hyposalivation and co‐morbidities. A potential …

It is now widely accepted that several gene alterations including transcription factors are
critically involved in cancer progression and metastasis. Forkhead Box Class O proteins …

Cancer is a complex disease and cancer cells typically harbor multiple genetic and
epigenetic alterations. Large-scale sequencing of patient-derived cancer samples has …

Overcoming acquired drug resistance remains a core challenge in the clinical management
of human cancer, including in urothelial carcinoma of the bladder (UCB). Cancer stem-like …