[HTML][HTML] The dual role of C/EBPδ in cancer

L Hartl, JW Duitman, MF Bijlsma, CA Spek - Critical Reviews in Oncology …, 2023 - Elsevier
Abstract CCAAT/Enhancer-Binding Protein delta (C/EBPδ) is a transcription factor involved
in differentiation and inflammation. While sparsely expressed in adult tissues, aberrant …

[HTML][HTML] The biological impacts of CEBPD on urothelial carcinoma development and progression

TC Chan, YL Shiue, CF Li - Frontiers in oncology, 2023 - frontiersin.org
Urothelial carcinoma (UC) which includes bladder urothelial carcinoma (UBUC) and upper
tract urothelial carcinoma (UTUC) is one of the most common malignancies worldwide …

[HTML][HTML] Angiogenesis driven by the CEBPD–hsa-miR-429–VEGFA signaling axis promotes urothelial carcinoma progression

TC Chan, CH Hsing, YL Shiue, SK Huang, KL Hsieh… - Cells, 2022 - mdpi.com
Background and Purpose: This research aimed to excavate the alternative mechanism of
CEBPD on tumor growth and explore the biological significance of the CEBPD/hsa-miR …

[HTML][HTML] C/EBPδ Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration

L Hartl, PAF Maarschalkerweerd, JM Butler, XD Manz… - Cells, 2022 - mdpi.com
Pancreatic Ductal Adenocarcinoma (PDAC) is among the most aggressive human cancers
and occurs globally at an increasing incidence. Metastases are the primary cause of cancer …

[HTML][HTML] The Janus kinase 1 is critical for pancreatic cancer initiation and progression

H Shrestha, PD Rädler, R Dennaoui, MN Wicker… - Cell Reports, 2024 - cell.com
Summary Interleukin-6 (IL-6)-class inflammatory cytokines signal through the Janus tyrosine
kinase (JAK)/signal transducer and activator of transcription (STAT) pathway and promote …

Biological significance of MYC and CEBPD coamplification in urothelial carcinoma: Multilayered genomic, transcriptional and posttranscriptional positive feedback …

TC Chan, YT Chen, KT Tan, CL Wu… - Clinical and …, 2021 - Wiley Online Library
Background and purpose The aim of this study is to decipher the underlying mechanisms of
CCAAT/enhancer‐binding protein delta (CEBPD)‐enhanced glycolysis as well as the …

[HTML][HTML] Milk-Derived miR-22-3p Promotes Proliferation of Human Intestinal Epithelial Cells (HIECs) by Regulating Gene Expression

R Jiang, B Lönnerdal - Nutrients, 2022 - mdpi.com
MicroRNA (miRNA) is small non-coding RNA involved in gene silencing and post-
transcriptional regulation of gene expression. Milk exosomes are microvesicles containing …

[HTML][HTML] Macrophage C/EBPδ Drives Gemcitabine, but Not 5-FU or Paclitaxel, Resistance of Pancreatic Cancer Cells in a Deoxycytidine-Dependent Manner

CA Spek, HL Aberson, JW Duitman - Biomedicines, 2022 - mdpi.com
Treatment of pancreatic ductal adenocarcinoma (PDAC), a dismal disease with poor survival
rates, is hampered by the high prevalence of chemotherapy resistance. Resistance is …

[HTML][HTML] Non-tumor CCAAT/Enhancer-binding protein delta potentiates tumor cell extravasation and pancreatic cancer metastasis formation

JW Duitman, L Hartl, JJTH Roelofs, MF Bijlsma… - Biomolecules, 2021 - mdpi.com
CCAAT/enhancer-binding protein delta (C/EBPδ) is a transcription factor involved in
apoptosis and proliferation, which is downregulated in pancreatic ductal adenocarcinoma …

[HTML][HTML] C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC

L Hartl, JJTH Roelofs, F Dijk, MF Bijlsma… - International journal of …, 2023 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease with a poor clinical
prognosis and unsatisfactory treatment options. We previously found that the transcription …