Targeting strategies for bone diseases: signaling pathways and clinical studies

H Xu, W Wang, X Liu, W Huang, C Zhu, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous
advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to …

[HTML][HTML] Recent developments in nanomaterials for upgrading treatment of orthopedics diseases

J Shang, C Zhou, C Jiang, X Huang, Z Liu… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Nanotechnology has changed science in the last three decades. Recent applications of
nanotechnology in the disciplines of medicine and biology have enhanced medical …

[HTML][HTML] Development of tetracycline-modified nanoparticles for bone-targeted delivery of anti-tubercular drug

Q Liang, P Zhang, L Zhang, H Luan, X Li… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Background: Since the poor response to existing anti-tuberculosis drugs and low drug
concentration in local bone tissues, the traditional drug therapy does not result in satisfactory …

mRNA nanodelivery systems: targeting strategies and administration routes

M Yuan, Z Han, Y Liang, Y Sun, B He… - Biomaterials …, 2023 - spj.science.org
With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid
(mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention …

Nanoparticle-Based Drug Delivery Systems for Enhancing Bone Regeneration

H Xu, Y Cui, Y Tian, M Dou, S Sun… - … Science & Engineering, 2024 - ACS Publications
The treatment of bone defects has been a long-standing challenge in clinical practice.
Among the various bone tissue engineering approaches, there has been substantial …

Bone Targeting Nanoparticles for the Treatment of Osteoporosis

C Wen, X Xu, Y Zhang, J Xia, Y Liang… - International Journal of …, 2024 - Taylor & Francis
Osteoporosis (OP) affects millions of people worldwide, especially postmenopausal women
and the elderly. Although current available anti-OP agents can show promise in slowing …

Integrating osteoimmunology and nanoparticle-based drug delivery systems for enhanced fracture healing

B Xiao, E Adjei-Sowah, DSW Benoit - … : Nanotechnology, Biology and …, 2023 - Elsevier
Fracture healing is a complex interplay of molecular and cellular mechanisms lasting from
days to weeks. The inflammatory phase is the first stage of fracture healing and is critical in …

An update on the advances in the field of nanostructured drug delivery systems for a variety of orthopedic applications

W Liang, C Zhou, S Jin, L Fu, H Zhang, X Huang… - Drug Delivery, 2023 - Taylor & Francis
Nanotechnology has made significant progress in various fields, including medicine, in
recent times. The application of nanotechnology in drug delivery has sparked a lot of …

Harnessing the Potential of PLGA Nanoparticles for Enhanced Bone Regeneration

M Hassan, HA Abdelnabi, S Mohsin - Pharmaceutics, 2024 - mdpi.com
Recently, nanotechnologies have become increasingly prominent in the field of bone tissue
engineering (BTE), offering substantial potential to advance the field forward. These …

[HTML][HTML] Citric acid-modified pH-sensitive bone-targeted delivery of estrogen for the treatment of postmenopausal osteoporosis

ZH Chen, DY Du, YF Fu, JJ Wu, DY Guo, YY Li… - Materials Today Bio, 2023 - Elsevier
Bone targeted delivery of estrogen offers great promise for the clinical application of
estrogen in the treatment of postmenopausal osteoporosis (PMOP). However, the current …