The majority of cardiovascular randomized controlled trials (RCTs) test interventions in
selected patient populations under explicitly protocol-defined settings. Although these …

Importance Randomized clinical trials (RCTs) provide the highest level of evidence to
evaluate 2 or more surgical interventions. Surgical RCTs, however, face unique challenges …

Evidence-based nutritional recommendations address the health impact of suboptimal
nutritional status. Efficacy randomized controlled trials (RCTs) have traditionally been the …

Pragmatic randomised clinical trials aim to directly inform clinical or health policy decision
making. Here, we systematically review methods and design of pragmatic trials of pain …

Many questions regarding the clinical management of people experiencing pain and related
health policy decision-making may best be answered by pragmatic controlled trials. To …

Background: Randomized controlled trials (RCTs) often target enrollment of patients with
demographics and outcomes less representative of the broader population of interest. To …

Despite increased available pain therapies, more than 50 to 100 million people in the United
States still live with pain and 20 million live with high-impact chronic pain that frequently …

Abstract Background First articulated by Schwartz and Lellouch (1967), randomized
controlled trials (RCTs) can be conceptualized along a continuum from more explanatory to …

Abstract Background Pragmatic clinical trials (PCTs) are designed to reflect how an
investigational treatment would be applied in clinical practice. As such, unlike their …

The pipeline of new cardiovascular drugs is relatively limited compared with many other
clinical areas. Challenges causing lagging drug innovation include the duration and …