[HTML][HTML] Multiple female reproductive failures in cyclooxygenase 2–deficient mice
H Lim, BC Paria, SK Das, JE Dinchuk, R Langenbach… - Cell, 1997 - cell.com
Cyclooxygenase (COX) is the rate-limiting enzyme in the synthesis of prostaglandins (PGs)
and exists in two isoforms, COX-1 and COX-2. In spite of long-standing speculation …
and exists in two isoforms, COX-1 and COX-2. In spite of long-standing speculation …
Anti-inflammatory drugs and their mechanism of action
JR Vane, RM Botting - Inflammation Research, 1998 - Springer
Nonsteroidal anti-inflammatory drugs (NSAIDs) produce their therapeutic activities through
inhibition of cyclooxygenase (COX), the enzyme that makes prostaglandins (PGs). They …
inhibition of cyclooxygenase (COX), the enzyme that makes prostaglandins (PGs). They …
Mechanism of action of nonsteroidal anti-inflammatory drugs
JR Vane, RM Botting - The American journal of medicine, 1998 - Elsevier
Salicylic acid and salicylates, obtained from natural sources, have long been used as
medicaments. Salicylic acid was chemically synthesized in 1860 and was used as an …
medicaments. Salicylic acid was chemically synthesized in 1860 and was used as an …
[HTML][HTML] Suppression of intestinal polyposis in ApcΔ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
M Oshima, JE Dinchuk, SL Kargman, H Oshima… - Cell, 1996 - cell.com
Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H
2: constitutive COX-1 and inducible COX-2. To assess the role of COX-2 in colorectal …
2: constitutive COX-1 and inducible COX-2. To assess the role of COX-2 in colorectal …
Inducible cyclooxygenase may have anti-inflammatory properties
DW Gilroy, PR Colville-Nash, D Willis, J Chivers… - Nature medicine, 1999 - nature.com
Cyclooxygenase (COX) has two isoforms. Generally, COX 1 is constitutively expressed in
most tissues, where it maintains physiological processes 1; inducible COX 2 is considered a …
most tissues, where it maintains physiological processes 1; inducible COX 2 is considered a …
Crush injuries with impairment of renal function
EGL Bywaters, D Beall - Br Med J, 1941 - Springer
The choice of papers for this collection of classical works is not based on the first description
of a subject, but has been directed toward their observations or studies that have either …
of a subject, but has been directed toward their observations or studies that have either …
Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2
BF McAdam, F Catella-Lawson… - Proceedings of the …, 1999 - National Acad Sciences
Prostaglandins (PG) are synthesized by two isoforms of the enzyme PG G/H synthase
[cyclooxygenase (COX)]. To examine selectivity of tolerated doses of an inhibitor of the …
[cyclooxygenase (COX)]. To examine selectivity of tolerated doses of an inhibitor of the …
New insights into the mode of action of anti-inflammatory drugs
JR Vane, RM Botting - Inflammation research, 1995 - Springer
The discovery of a second cyclooxygenase has provided fresh impetus to the search for new
anti-inflammatory drugs. The second enzyme is effectively absent from healthy tissues but its …
anti-inflammatory drugs. The second enzyme is effectively absent from healthy tissues but its …
The mechanisms of action of NSAIDs in analgesia
JN Cashman - Drugs, 1996 - Springer
Traditionally, the analgesic action of nonsteroidal anti-inflammatory drugs (NSAIDs) has
been explained on the basis of their inhibition of the enzymes that synthesise …
been explained on the basis of their inhibition of the enzymes that synthesise …
Mechanism of action of paracetamol
Paracetamol (acetaminophen) is generally considered to be a weak inhibitor of the
synthesis of prostaglandins (PGs). However, the in vivo effects of paracetamol are similar to …
synthesis of prostaglandins (PGs). However, the in vivo effects of paracetamol are similar to …