Bacteria-inspired transformable nanoparticle targets and covers residual tumor against bladder cancer recurrence

J Wang, P Yang, D Hou, Y Yan, K Yue, W Zhong… - Nano Today, 2022 - Elsevier
The regrowth of residual tumor left by incomplete surgery leads to bladder cancer
recurrence. Postoperative intravesical instillation in clinic shows unsatisfactory recurrence …

Bioadhesive supramolecular hydrogel from unprotected, short D, L-peptides with Phe-Phe and Leu-Asp-Val motifs

MC Cringoli, C Romano, E Parisi… - Chemical …, 2020 - pubs.rsc.org
The uncapped tripeptide DPhe-Phe-Leu acts as self-assembly template to yield
supramolecular hydrogel biomaterials. As an example, self-assembling DPhe-Phe-Leu-Asp …

Self‐assembly of an amino acid derivative into an antimicrobial hydrogel biomaterial

AM Garcia, R Lavendomme, S Kralj… - … A European Journal, 2020 - Wiley Online Library
Abstract N‐(4‐Nitrobenzoyl)‐Phe self‐assembled into a transparent supramolecular
hydrogel, which displayed high fibroblast and keratinocyte cell viability. The compound …

Embedding and Positioning of Two FeII4L4 Cages in Supramolecular Tripeptide Gels for Selective Chemical Segregation

M Kieffer, AM Garcia, CJE Haynes, S Kralj… - Angewandte …, 2019 - Wiley Online Library
An unreported d, l‐tripeptide self‐assembled into gels that embedded FeII4L4 metal–
organic cages to form materials that were characterized by TEM, EDX, Raman spectroscopy …

[HTML][HTML] Supramolecular peptide nanostructures: Self-assembly and biomedical applications

Z Du, B Fan, Q Dai, L Wang, J Guo, Z Ye, N Cui, J Chen… - Giant, 2022 - Elsevier
To mimic proteins, artificial designed self-assembling peptides (SAPs) that form diverse
ordered nanostructures have been developed and served in biomedicine fields. In this …

Less is More: Preorganization leads to better tumor retention and therapeutic efficacy

L Xie, Y Ding, Y Wang, X Li, Z Yang… - Advanced Functional …, 2022 - Wiley Online Library
Protein preorganization is ubiquitous in nature and enables subtle structural
rearrangements and precise function executions, making it an attractive approach for …

Enantiomorphic Microvortex‐Enabled Supramolecular Sensing of Racemic Amino Acids by Using Achiral Building Blocks

Y Li, C Liu, X Bai, F Tian, G Hu… - Angewandte Chemie …, 2020 - Wiley Online Library
Chiral analysis of bioactive molecules is of increasing significance in chemical and life
sciences. However, the quantitative detection of a racemic mixture of enantiomers is a …

Protein‐Based Controllable Nanoarchitectonics for Desired Applications

L Li, Y Zhang, Y Wu, Z Wang, W Cui… - Advanced Functional …, 2024 - Wiley Online Library
Controllable protein nanoarchitectonics refers to the process of manipulating and controlling
the assembly of proteins at the nanoscale to achieve domain‐limited and accurate spatial …

Self‐assembling tripeptide forming water‐bound channels and hydrogels

E Parisi, S Adorinni, AM Garcia, S Kralj… - Journal of Peptide …, 2023 - Wiley Online Library
D‐Ser (tBu)‐L‐Phe‐L‐Trp is described as a self‐assembling tripeptide that yields
nanofibrillar hydrogels at physiological conditions (phosphate buffer at pH 7.4). The peptide …

In vivo mitigation of amyloidogenesis through functional–pathogenic double-protein coronae

I Javed, T Yu, G Peng, A Sánchez-Ferrer, A Faridi… - Nano …, 2018 - ACS Publications
Amyloid diseases are global epidemics with no cure available. Herein, we report a first
demonstration of in vivo mitigation of amyloidogenesis using biomimetic nanotechnology …