Background: Sepsis is a life-threatening condition responsible for up to 20% of all global
deaths. Kidneys are among the most common organs implicated, yet the pathogenesis of …

Neprilysin is a cell surface metallo-endopeptidase, commonly identified as neutral
endopeptidase (NEP), that plays a crucial role in the cleavage of peptides, for example …

Abstract Angiotensin converting enzyme 2 (ACE2) is a new identified member of the renin-
angiotensin-aldosterone system (RAAS) that cleaves angiotensin II (Ang II) to Ang (1–7) …

This study investigated the synergistic protective effects of melatonin (MEL) and ascorbic
acid (vitamin C, ASA) in treating sepsis‐induced lung injury in rats. Rats were divided into …

The renin-angiotensin-aldosterone system (RAAS) is an important pathway that contributes
to the pathophysiology of acute liver injury due to paracetamol toxicity. Omapatrilat, a RAAS …

Natriuretic peptide system (NPS) is a group of peptide hormones or paracrine factors,
including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and natriuretic …

Sepsis is a syndrome that includes physiological, pathological, and biochemical
abnormalities resulting from the host immune response to infection. Despite the improved …

Abstract Purpose/Aims This study focused on delineating the possible effects of roflumilast
(ROF), a selective phosphodiesterase 4 (PDE4) inhibitor, in rats with cecal ligation and …

Sepsis is a major health problem that causes millions of deaths worldwide every year. Due
to the complexity of its pathophysiology, there is no clear treatment method for it. Existing …

Sepsis represents a major contributor to mortality among critically ill patients, imposing a
substantial economic strain on health-care systems. The uncontrolled inflammatory …