Aging is usually considered a key risk factor associated with multiple diseases, such as
neurodegenerative diseases, cardiovascular diseases and cancer. Furthermore, the burden …

In recent years, advances in science and technology have improved our quality of life,
enabling us to tackle diseases and increase human life expectancy. However, longevity is …

Alzheimer's disease is the most common age-associated neurodegenerative disorder and
the most frequent form of dementia in our society. Aging is a complex biological process …

Long-term maintenance of synaptic connections is important for brain function, which
depends on varying proteostatic regulations to govern the functional integrity of neuronal …

The elevated occurrence of debilitating neurodegenerative disorders, such as amyotrophic
lateral sclerosis (ALS), Huntington's disease (HD), Alzheimer's disease (AD), Parkinson's …

Progeroid syndromes are characterized by clinical signs of premature ageing, which may
contain several diseases such as Werner syndrome, Bloom syndrome, Rothmund-Thomson …

Background Aging is the primary risk factor of most chronic diseases in humans, including
cardiovascular diseases, osteoporosis and neurodegenerative diseases, which extensively …

Introduction Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease
characterized by the progressive loss of motor neurons. Several animal models have been …

The nematode Caenorhabditis elegans are a powerful model system to study human
disease, with numerous experimental advantages including significant genetic and cellular …

Amyotrophic Lateral Sclerosis (ALS) is a debilitating neurodegenerative condition
characterized by the progressive degeneration of motor neurons. Despite extensive …