Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …

DNA obtained from environmental samples such as sediments, ice or water (environmental
DNA, eDNA), represents an important source of information on past and present biodiversity …

Determining the extent of overlap between modern humans and other hominins in Eurasia,
such as Neanderthals and Denisovans, is fundamental to understanding the nature of their …

Background As high-throughput sequencing platforms produce longer and longer reads,
sequences generated from short inserts, such as those obtained from fossil and degraded …

The human occupation history of Southeast Asia (SEA) remains heavily debated. Current
evidence suggests that SEA was occupied by Hòabìnhian hunter-gatherers until~ 4000 …

The geographic and temporal origins of dogs remain controversial. We generated genetic
sequences from 59 ancient dogs and a complete (28x) genome of a late Neolithic dog …

Present-day hunter-gatherers (HGs) live in multilevel social groups essential to sustain a
population structure characterized by limited levels of within-band relatedness and …

Background Cytosine DNA methylation is widely described as a transcriptional repressive
mark with the capacity to silence promoters. Epigenome engineering techniques enable …

Background The automated reconstruction of genome sequences in ancient genome
analysis is a multifaceted process. Results Here we introduce EAGER, a time-efficient …

In recent years, massive parallel sequencing has revolutionised the study of degraded DNA,
thus enabling the field of ancient DNA to evolve into that of paleogenomics. Despite these …