There has been a long-standing debate to explain the complex correlation of development
of human hand preference with brain lateralization, and occasionally, the correlation of both …

▪ Abstract Gene finding in genetically complex diseases has been difficult as a result of many
factors that have diagnostic and methodologic considerations. For bipolar disorder and …

The present study reports a genomewide scan using linkage analysis for risk genes involved
in bipolar disorder with 613 microsatellite markers including additional testing of promising …

In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on
chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion …

Objectives: To review the methodologies and findings in the genetics of bipolar disorder
(BPD), and to suggest future directions for research. Methods: Reports of family, twin …

Genes involved in the regulation of synaptic vesicle function are potential candidates for the
development of psychiatric disorders. In addition to experimental and theoretical …

Bipolar affective disorder (BAD) affects∼ 1% of the population and shows strong heritability.
To identify potential BAD susceptibility loci, we undertook a 15-cM genome screen, using …

Linkage analysis has shown that chromosome 21q22 may contain a candidate gene for
bipolar disorder (BPD). One potential 21q22 candidate gene we previously analyzed is …

The identification of genes responsible for mood disorders will contribute to significant
advances in the awareness of diagnosis (diagnostic process and early recognition) …

Clinical anticipation has been reported in bipolar affective disorder (BPAD). The hypothesis
that expanded trinucleotide repeats are related to anticipation and transmission pattern in …