Objectives The conventional dissolution test, particularly the USP apparatus I and II, remains
an important tool in the armory of the pharmaceutical development scientist. For realistic …

Compromised oral drug absorption, due to poor aqueous solubility, is one of the major
challenges faced by the pharmaceutical industry in the drug discovery and development …

Physiologically based pharmacokinetic (PBPK) absorption modeling and simulation is
increasingly used as a tool in drug product development, not only in support of clinical …

The influence of polymers on the dissolution, supersaturation, crystallization, and
partitioning of poorly water soluble compounds in biphasic media was evaluated …

Biphasic dissolution systems achieved good predictability for the in vivo performance of
several formulations of poorly water-soluble drugs by characterizing dissolution …

Amorphous solid dispersions (ASDs) have been proven to increase the bioavailability of
poorly soluble drugs. It is desirable that the ASD provide a rapid dissolution rate and a …

In vitro dissolution methods correctly predicting in vivo bioavailability of compounds from
complex mixtures are lacking. We therefore used data on the in vivo performance of …

Abstract USP apparatus I and II are gold standard methodologies for determining the in vitro
dissolution profiles of test drugs. However, it is difficult to use in vitro dissolution results to …

Pharmaceutical formulations have to fulfil various requirements with respect to their intended
use, either in the development phase or as a commercial product. New drug candidates with …

In vitro dissolution methodologies that adequately capture the oral bioperformance of solid
dosage forms are critical tools needed to aid formulation development. Such methodologies …