Impact of predictive, preventive and precision medicine strategies in epilepsy
R Nabbout, M Kuchenbuch - Nature Reviews Neurology, 2020 - nature.com
Over the last decade, advances in genetics, neuroimaging and EEG have enabled the
aetiology of epilepsy to be identified earlier in the disease course than ever before. At the …
aetiology of epilepsy to be identified earlier in the disease course than ever before. At the …
[HTML][HTML] Genetic landscape of common epilepsies: advancing towards precision in treatment
Epilepsy, a neurological disease characterized by recurrent seizures, is highly
heterogeneous in nature. Based on the prevalence, epilepsy is classified into two types …
heterogeneous in nature. Based on the prevalence, epilepsy is classified into two types …
Phenytoin–An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology
Phenytoin is a long-standing, anti-seizure drug widely used in clinical practice. It has also
been evaluated in the context of many other illnesses in addition to its original epilepsy …
been evaluated in the context of many other illnesses in addition to its original epilepsy …
Clinical application of next-generation sequencing to the practice of neurology
J Rexach, H Lee, JA Martinez-Agosto… - The Lancet …, 2019 - thelancet.com
Next-generation sequencing technologies allow for rapid and inexpensive large-scale
genomic analysis, creating unprecedented opportunities to integrate genomic data into the …
genomic analysis, creating unprecedented opportunities to integrate genomic data into the …
[HTML][HTML] Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs
OA Badary - The Pharmacogenomics Journal, 2021 - nature.com
The outbreak of Coronavirus disease 2019 (COVID-19) has evolved into an emergent global
pandemic. Many drugs without established efficacy are being used to treat COVID-19 …
pandemic. Many drugs without established efficacy are being used to treat COVID-19 …
[HTML][HTML] Genomic risk factors driving immune-mediated delayed drug hypersensitivity reactions
Y Li, P Deshpande, RJ Hertzman, AM Palubinsky… - Frontiers in …, 2021 - frontiersin.org
Adverse drug reactions (ADRs) remain associated with significant mortality. Delayed
hypersensitivity reactions (DHRs) that occur greater than 6 h following drug administration …
hypersensitivity reactions (DHRs) that occur greater than 6 h following drug administration …
Developing a gene panel for pharmacoresistant epilepsy: a review of epilepsy pharmacogenetics
Evaluating genes involved in the pharmacodynamics and pharmacokinetics of epilepsy
drugs is critical to better understand pharmacoresistant epilepsy. We reviewed the …
drugs is critical to better understand pharmacoresistant epilepsy. We reviewed the …
Sexual dimorphism in drug metabolism and pharmacokinetics
AM Valodara, KJ SR - Current Drug Metabolism, 2019 - ingentaconnect.com
Background: Sex and gender-based differences are observed well beyond the sex organs
and affect several physiological and biochemical processes involved in the metabolism of …
and affect several physiological and biochemical processes involved in the metabolism of …
An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects
Introduction Phenytoin is a frequently used drug treatment for epilepsy. Genetic
polymorphisms in the metabolism of phenytoin, particularly CYP2C9, are strongly …
polymorphisms in the metabolism of phenytoin, particularly CYP2C9, are strongly …
Racial and ethnic differences in antiseizure medications among people with epilepsy on Medicaid: A case of potential inequities
WP Bensken, G Fernandez Baca Vaca… - Neurology: Clinical …, 2023 - AAN Enterprises
Background and Objectives Being on a newer, second-, and third-generation antiseizure
medication (ASM) may represent an important marker of quality of care for people with …
medication (ASM) may represent an important marker of quality of care for people with …