Pain measures traditionally used in rodents record mere reflexes evoked by sensory stimuli;
the results thus may not fully reflect the human pain phenotype. Alterations in physical and …

Inflammatory pain is the most common type of pain that is treated clinically. The use of
currently available treatments (classic analgesics-NSAIDs, paracetamol and opioids) is …

Background Pain is reported as the leading cause of disability in the common forms of
inflammatory arthritis conditions. Acting as a key player in nociceptive processing …

Chronic pain hypersensitivity depends on N-methyl-d-aspartate receptors (NMDARs).
However, clinical use of NMDAR blockers is limited by side effects resulting from …

Background and purpose: The phytocannabinoid, Δ9‐tetrahydrocannabivarin (THCV), can
block cannabinoid CB1 receptors. This investigation explored its ability to activate CB2 …

Background and purpose: N‐arachidonoyl‐serotonin (AA‐5‐HT) is an inhibitor of fatty acid
amide hydrolase (FAAH)‐catalysed hydrolysis of the endocannabinoid/endovanilloid …

Neurotensin (NT) has emerged as an important modulator of nociceptive transmission and
exerts its biological effects through interactions with 2 distinct GPCRs, NTS1 and NTS2. NT …

ETHNOPHARMACOLOGICAL RELEVANCE: Corilagin (β-1-O-galloyl-3, 6-(R)-
hexahydroxydiphenoyl-d-glucose) is a tannin isolated from Phyllanthus niruri …

The aim of this research was to assess the antinociceptive activity of the transient receptor
potential (TRP) channel TRPV1, TRPM8, and TRPA1 antagonists in neurogenic, tonic, and …

The constant refinement of tests used in animal research is crucial for the scientific
community. This is particularly true for the field of pain research, where ethical standards are …