A decoction prepared from the aerial parts of Melampodium divaricatum showed
antinociceptive and antihyperalgesic responses when tested in the formalin model in mice …

Abstract Preclinical Research Analgesics with different mechanisms of action can be
combined in order to obtain pharmacological synergism, employing lower doses of each …

Glutamate (which facilitates peripheral nociception) releases adenosine (which inhibits
peripheral nociception via adenosine A1 receptors) when injected locally into the rat …

Src family of kinases (SFKs) has been found to play an important role in the regulation of
nociception. However, how each member of this family acts in the central nervous system …

The present study has explored the hypothesis that neurokinin1 receptors (NK1Rs) in
medial septum (MS) modulate nociception evoked on hind paw injection of formalin. Indeed …

Objectives Body protective compound-157 (BPC-157) is a stable gastric pentadecapeptide
that has been effective in trials aiming to increase wound healing capabilities and decrease …

Mice lacking the adenosine A2A receptor are less sensitive to nociceptive stimuli, and A2A
receptor antagonists have antinociceptive effects. We have previously shown a marked …

The goal of the study was to assess the analgesic and anti-inflammatory properties of
montelukast in chicks. Methods: The oral median analgesic effective dose (ED50) of …

The 6-methoxy-2-phenylimidazo [1, 2-b] pyridazine-3-carboxylic acid, DM2, exerts anti-
absence activity and blocks Cav3. 1 channel, a T-type voltage-dependent Ca2+ channel …

The naked mole rat (NMR) is a rodent that has gained importance as a biomedical research
model for various conditions like hypoxic brain injury, cancer and nociception. This study …