A cell surface receptor for thyroid hormone that activates extracellular regulated kinase
(ERK) 1/2 has been identified on integrin αvβ3. We have examined the actions of thyroid …

Cell targeting peptides (CTP) are small peptides which have high affinity and specificity to a
cell or tissue targets. They are typically identified by using phage display and chemical …

The syndecans are a family of heparan sulfate‐decorated cell‐surface proteoglycans: matrix
receptors with roles in cell adhesion and growth factor signaling. Their heparan sulfate …

Background: Integrins are a family of transmembrane receptors that mediate cell-cell and
cell-matrix adhesion. They are involved in stable cell adhesion and migration of cells. In …

Cyclic RGD peptide-decorated polymeric micellar-like nanoparticles (MNP) based on
PEGylated poly (trimethylene carbonate)(PEG-PTMC) were prepared for active targeting to …

Following injurious stimuli, quiescent hepatic stellate cells (qHSCs) transdifferentiate into
activated HSCs (aHSCs). aHSCs play pivotal roles in the onset and progression of liver …

The traditional “one treatment fits all” paradigm disregards the heterogeneity between
cancer patients, and within a particular tumor, thus limit the success of common treatments …

Abstract Purpose Various radiolabeled Arg-Gly-Asp (RGD) peptides have been previously
investigated for tumor integrin α v β 3 imaging. To further develop RGD radiotracers with …

The tumor microenvironment provides a rich source of potential targets for selective
therapeutic intervention with properly designed anticancer agents. Significant physiological …

Proteins are essential for life, as they participate in all vital processes in the body. In the past
decade, delivery of active proteins to specific cells and organs has attracted increasing …