Glycoconjugates: synthesis, functional studies, and therapeutic developments
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
Yeast expression systems: overview and recent advances
Yeasts are outstanding hosts for the production of functional recombinant proteins with
industrial or medical applications. Great attention has been emerged on yeast due to the …
industrial or medical applications. Great attention has been emerged on yeast due to the …
Half-life extended biotherapeutics
RE Kontermann - Expert opinion on biological therapy, 2016 - Taylor & Francis
Introduction: Many of the biotherapeutics approved or under development suffer from a short
half-life necessitating frequent applications in order to maintain a therapeutic concentration …
half-life necessitating frequent applications in order to maintain a therapeutic concentration …
[HTML][HTML] Principles of N-Linked Glycosylation Variations of IgG-Based Therapeutics: Pharmacokinetic and Functional Considerations
S Boune, P Hu, AL Epstein, LA Khawli - Antibodies, 2020 - mdpi.com
The development of recombinant therapeutic proteins has been a major revolution in
modern medicine. Therapeutic-based monoclonal antibodies (mAbs) are growing rapidly …
modern medicine. Therapeutic-based monoclonal antibodies (mAbs) are growing rapidly …
[HTML][HTML] Antibody engineering for pursuing a healthier future
AFUH Saeed, R Wang, S Ling, S Wang - Frontiers in microbiology, 2017 - frontiersin.org
Since the development of antibody-production techniques, a number of immunoglobulins
have been developed on a large scale using conventional methods. Hybridoma technology …
have been developed on a large scale using conventional methods. Hybridoma technology …
[HTML][HTML] Genetic glycoengineering in mammalian cells
Advances in nuclease-based gene-editing technologies have enabled precise, stable, and
systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …
systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …
[HTML][HTML] Glycans in drug discovery
P Valverde, A Ardá, NC Reichardt… - …, 2019 - pubs.rsc.org
Glycans are key players in many biological processes. They are essential for protein folding
and stability and act as recognition elements in cell–cell and cell–matrix interactions. Thus …
and stability and act as recognition elements in cell–cell and cell–matrix interactions. Thus …
[HTML][HTML] N-glycosylation of the SARS-CoV-2 receptor binding domain is important for functional expression in plants
YJ Shin, J König-Beihammer, U Vavra… - Frontiers in Plant …, 2021 - frontiersin.org
Nicotiana benthamiana is used worldwide as production host for recombinant proteins.
Many recombinant proteins such as monoclonal antibodies, growth factors or viral antigens …
Many recombinant proteins such as monoclonal antibodies, growth factors or viral antigens …
Preclinical evaluation of a plant-derived SARS-CoV-2 subunit vaccine: Protective efficacy, immunogenicity, safety, and toxicity
B Shanmugaraj, N Khorattanakulchai, C Panapitakkul… - Vaccine, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is an acute respiratory illness caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The prevention of SARS …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The prevention of SARS …
[HTML][HTML] Protein glycoengineering: an approach for improving protein properties
B Ma, X Guan, Y Li, S Shang, J Li, Z Tan - Frontiers in Chemistry, 2020 - frontiersin.org
Natural proteins are an important source of therapeutic agents and industrial enzymes.
While many of them have the potential to be used as highly effective medical treatments for a …
While many of them have the potential to be used as highly effective medical treatments for a …