[HTML][HTML] In vitro and ex vivo models in inhalation biopharmaceutical research—advances, challenges and future perspectives

MA Selo, JA Sake, KJ Kim, C Ehrhardt - Advanced Drug Delivery Reviews, 2021 - Elsevier
Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side
effects, making it the preferred means of drug delivery for the treatment of respiratory …

Innovative preclinical models for pulmonary drug delivery research

S Ehrmann, O Schmid, C Darquenne… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: Pulmonary drug delivery is a complex field of research combining physics
which drive aerosol transport and deposition and biology which underpins efficacy and …

Breathing in vitro: Designs and applications of engineered lung models

R Nossa, J Costa, L Cacopardo… - Journal of tissue …, 2021 - journals.sagepub.com
The aim of this review is to provide a systematic design guideline to users, particularly
engineers interested in developing and deploying lung models, and biologists seeking to …

Simulating alveoli-inspired air pockets in a ZnO/NiMoO4/C3N4 catalyst filter for toluene entrapment and photodecomposition

H Anwer, M Ali, S Lee, SH Jeong, JW Park - Journal of Hazardous Materials, 2021 - Elsevier
Here, we propose an alveoli–inspired catalyst to address the susceptibility of photocatalytic
air oxidation systems to fluctuations in volatile organic contaminant (VOC) loads. An alveoli …

Optimizing the design and dosing of dry powder inhaler formulations of the cationic liposome adjuvant CAF® 01 for pulmonary immunization

A Thakur, Y Xu, G Cano-Garcia, S Feng… - Frontiers in Drug …, 2022 - frontiersin.org
Thermostability is one of the product characteristics preferred by WHO for vaccines against
respiratory infections due to ease of administration, pain minimization, and low costs …

Dry powder inhaler formulation comparison: Study of the role of particle deposition pattern and dissolution

B Noriega-Fernandes, M Malmlöf, M Nowenwik… - International Journal of …, 2021 - Elsevier
The composition, morphology and dissolution profile of particles and micro-sized
agglomerates delivered upon inhalation may have a significant impact on the product …

[HTML][HTML] In Vitro to ex Vivo/In Vivo Correlation (IVIVC) of dissolution kinetics from inhaled particulate solutes using air/blood barrier models: Relation between in vitro …

P Gerde, M Malmlöf, E Selg - Journal of Aerosol Science, 2021 - Elsevier
Correlating data from in vitro dissolution testing of inhaled particulate pharmaceuticals or air
pollutants with the dissolution and distribution to the blood circulation of the same aerosols …

Reconstituted dry powder formulations of ZnO-adjuvanted ovalbumin induce equivalent antigen specific antibodies but lower T cell responses than ovalbumin …

M Hellfritzsch, D Christensen, C Foged… - International Journal of …, 2023 - Elsevier
Most licensed human vaccines are based on liquid dosage forms but have poor storage
stability and require continuous and expensive cold-chain storage. In contrast, the use of …

[HTML][HTML] Regional lung targeting with a fluticasone/salmeterol aerosol using a bolus breath hold method of the PreciseInhale® system: A first evaluation in humans

P Gerde, CO Sjöberg, H Bäckroos, J Englund… - European Journal of …, 2024 - Elsevier
Background In development of inhaled drugs-and formulations the measured concentration
in the systemic circulation is often used as a surrogate for local dosimetry in the lungs. To …

Bioavailability of inhaled or ingested PFOA adsorbed to house dust

Å Gustafsson, B Wang, P Gerde, Å Bergman… - … Science and Pollution …, 2022 - Springer
Indoor environments may impact human health due to chemical pollutants in the indoor air
and house dust. This study aimed at comparing the bioavailability and distribution of PFOA …