[HTML][HTML] In vitro and ex vivo models in inhalation biopharmaceutical research—advances, challenges and future perspectives
Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side
effects, making it the preferred means of drug delivery for the treatment of respiratory …
effects, making it the preferred means of drug delivery for the treatment of respiratory …
Innovative preclinical models for pulmonary drug delivery research
Introduction: Pulmonary drug delivery is a complex field of research combining physics
which drive aerosol transport and deposition and biology which underpins efficacy and …
which drive aerosol transport and deposition and biology which underpins efficacy and …
Breathing in vitro: Designs and applications of engineered lung models
R Nossa, J Costa, L Cacopardo… - Journal of tissue …, 2021 - journals.sagepub.com
The aim of this review is to provide a systematic design guideline to users, particularly
engineers interested in developing and deploying lung models, and biologists seeking to …
engineers interested in developing and deploying lung models, and biologists seeking to …
Simulating alveoli-inspired air pockets in a ZnO/NiMoO4/C3N4 catalyst filter for toluene entrapment and photodecomposition
Here, we propose an alveoli–inspired catalyst to address the susceptibility of photocatalytic
air oxidation systems to fluctuations in volatile organic contaminant (VOC) loads. An alveoli …
air oxidation systems to fluctuations in volatile organic contaminant (VOC) loads. An alveoli …
Optimizing the design and dosing of dry powder inhaler formulations of the cationic liposome adjuvant CAF® 01 for pulmonary immunization
Thermostability is one of the product characteristics preferred by WHO for vaccines against
respiratory infections due to ease of administration, pain minimization, and low costs …
respiratory infections due to ease of administration, pain minimization, and low costs …
Dry powder inhaler formulation comparison: Study of the role of particle deposition pattern and dissolution
B Noriega-Fernandes, M Malmlöf, M Nowenwik… - International Journal of …, 2021 - Elsevier
The composition, morphology and dissolution profile of particles and micro-sized
agglomerates delivered upon inhalation may have a significant impact on the product …
agglomerates delivered upon inhalation may have a significant impact on the product …
[HTML][HTML] In Vitro to ex Vivo/In Vivo Correlation (IVIVC) of dissolution kinetics from inhaled particulate solutes using air/blood barrier models: Relation between in vitro …
P Gerde, M Malmlöf, E Selg - Journal of Aerosol Science, 2021 - Elsevier
Correlating data from in vitro dissolution testing of inhaled particulate pharmaceuticals or air
pollutants with the dissolution and distribution to the blood circulation of the same aerosols …
pollutants with the dissolution and distribution to the blood circulation of the same aerosols …
Reconstituted dry powder formulations of ZnO-adjuvanted ovalbumin induce equivalent antigen specific antibodies but lower T cell responses than ovalbumin …
M Hellfritzsch, D Christensen, C Foged… - International Journal of …, 2023 - Elsevier
Most licensed human vaccines are based on liquid dosage forms but have poor storage
stability and require continuous and expensive cold-chain storage. In contrast, the use of …
stability and require continuous and expensive cold-chain storage. In contrast, the use of …
[HTML][HTML] Regional lung targeting with a fluticasone/salmeterol aerosol using a bolus breath hold method of the PreciseInhale® system: A first evaluation in humans
P Gerde, CO Sjöberg, H Bäckroos, J Englund… - European Journal of …, 2024 - Elsevier
Background In development of inhaled drugs-and formulations the measured concentration
in the systemic circulation is often used as a surrogate for local dosimetry in the lungs. To …
in the systemic circulation is often used as a surrogate for local dosimetry in the lungs. To …
Bioavailability of inhaled or ingested PFOA adsorbed to house dust
Å Gustafsson, B Wang, P Gerde, Å Bergman… - … Science and Pollution …, 2022 - Springer
Indoor environments may impact human health due to chemical pollutants in the indoor air
and house dust. This study aimed at comparing the bioavailability and distribution of PFOA …
and house dust. This study aimed at comparing the bioavailability and distribution of PFOA …