Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

Pharmacometabolomics (PMx) studies use information contained in metabolic profiles (or
metabolome) to inform about how a subject will respond to drug treatment. Genome, gut …

Epigenetics is the study of heritable and non-heritable genetic coding that is additive to
information contained within classical DNA base pair sequences. Differential methylation …

Time separates the past from the present, during this period memory are formed-written in
code and decoded to be read while other memories are erased-but when it comes to the …

Epigenetics functions as a bridge between host genetic & environmental factors, aiding in
human health and diseases. Many immune-related diseases, including infectious and …

Alzheimer's disease is a progressive neurodegenerative disorder and the most common
cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative …

Breast cancer cell lines lose the inherent gene expression profiles of their source tumor and
when cultured as monolayers (two-dimensional) are unable to represent patient tumors …

Diagnostic Molecular Biology, Second Edition describes the fundamentals of molecular
biology in a clear, concise manner with each technique explained within its conceptual …

Precision medicine is driven by the paradigm shift of empowering clinicians to predict the
most appropriate course of action for patients with complex diseases and to improve routine …